Giant Cell Tumor of Bone in Patients under 16 Years Old: A Single-Institution Case Series.
H3F3A
bone
giant cell tumor
immunohistochemistry
pediatric
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 May 2021
25 May 2021
Historique:
received:
30
03
2021
revised:
17
05
2021
accepted:
21
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Giant cell tumor of bone is a locally aggressive, rarely metastasizing tumor that accounts for about 5% of bone tumors and generally occurs in patients between 20 and 45 years old. A driver mutation in the histone 3.3 (H3.3) gene All cases of giant cell tumor of bone in pediatric patients <16 years old treated in our institute between 1982 and 2018 were reviewed. Immunohistochemistry and/or molecular analysis for Fifteen cases were retrieved. A pronounced female predominance (93%) was observed. A pure metaphyseal central location occurs in 2 skeletally immature patients. Giant cell tumor of bone should be distinguished from its mimickers due to differences in prognosis and treatment. Immunohistochemical and molecular detection of
Sections du résumé
BACKGROUND
BACKGROUND
Giant cell tumor of bone is a locally aggressive, rarely metastasizing tumor that accounts for about 5% of bone tumors and generally occurs in patients between 20 and 45 years old. A driver mutation in the histone 3.3 (H3.3) gene
METHODS
METHODS
All cases of giant cell tumor of bone in pediatric patients <16 years old treated in our institute between 1982 and 2018 were reviewed. Immunohistochemistry and/or molecular analysis for
RESULTS
RESULTS
Fifteen cases were retrieved. A pronounced female predominance (93%) was observed. A pure metaphyseal central location occurs in 2 skeletally immature patients.
CONCLUSIONS
CONCLUSIONS
Giant cell tumor of bone should be distinguished from its mimickers due to differences in prognosis and treatment. Immunohistochemical and molecular detection of
Identifiants
pubmed: 34070432
pii: cancers13112585
doi: 10.3390/cancers13112585
pmc: PMC8197501
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Cancer. 2003 May 15;97(10):2520-9
pubmed: 12733152
Verh Dtsch Ges Pathol. 1998;82:154-9
pubmed: 10095427
J Clin Pathol. 2016 Mar;69(3):240-7
pubmed: 26338802
J Bone Joint Surg Am. 1987 Jan;69(1):106-14
pubmed: 3805057
Histopathology. 2017 Sep;71(3):453-460
pubmed: 28477388
Radiographics. 2001 Sep-Oct;21(5):1283-309
pubmed: 11553835
Skeletal Radiol. 2003 Mar;32(3):147-50
pubmed: 12605279
Am J Hum Genet. 2016 Feb 4;98(2):275-86
pubmed: 26849110
Int Orthop. 2006 Dec;30(6):499-504
pubmed: 16909252
Hum Pathol. 2018 Mar;73:41-50
pubmed: 29241742
J Bone Miner Res. 2006 Dec;21(12):1828-35
pubmed: 17002563
Arch Pathol Lab Med. 2013 Sep;137(9):1296-303
pubmed: 23991743
World J Pediatr. 2020 Oct;16(5):520-527
pubmed: 32776272
Am J Surg Pathol. 2016 Dec;40(12):1702-1712
pubmed: 27526293
Hum Pathol. 2017 Oct;68:128-135
pubmed: 28899740
Am J Surg Pathol. 2017 Aug;41(8):1059-1068
pubmed: 28505000
J Pediatr Orthop. 2007 Sep;27(6):635-9
pubmed: 17717462
Cancer. 1970 May;25(5):1061-70
pubmed: 4910256
Cancer. 1979 Oct;44(4):1393-402
pubmed: 227563
Pathol Res Pract. 2018 Jan;214(1):89-94
pubmed: 29254795
J Bone Joint Surg Am. 1983 Apr;65(4):486-90
pubmed: 6833323
Virchows Arch. 2012 Mar;460(3):327-34
pubmed: 22350004
Sarcoma. 2016;2016:3079835
pubmed: 27999474
Nat Genet. 2013 Dec;45(12):1479-82
pubmed: 24162739