Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension.
endothelial cells
pericytes
progenitor cells
pulmonary arterial hypertension
smooth muscle cells
stem cells
vascular remodeling
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
28
04
2021
revised:
12
05
2021
accepted:
21
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular remodeling with the production of new endothelial cells, smooth muscle cells, myofibroblasts, and fibroblasts. Identifying the cellular processes leading to vascular proliferation and dysfunction is a major goal in order to decipher the mechanisms leading to PAH development. In addition to in situ proliferation of vascular cells, studies from the past 20 years have unveiled the role of circulating and resident vascular in pulmonary vascular remodeling. This review aims at summarizing the current knowledge on the different progenitor and stem cells that have been shown to participate in pulmonary vascular lesions and on the pathways regulating their recruitment during PAH. Finally, this review also addresses the therapeutic potential of circulating endothelial progenitor cells and mesenchymal stem cells.
Identifiants
pubmed: 34071347
pii: cells10061338
doi: 10.3390/cells10061338
pmc: PMC8226806
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
Pays : Canada
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