Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection.
Alzheimer Disease
/ drug therapy
Animals
Biomarkers
Brain-Derived Neurotrophic Factor
/ genetics
Cell Survival
/ drug effects
Disease Management
Disease Susceptibility
Flavonoids
/ pharmacology
Humans
Molecular Targeted Therapy
Neuronal Plasticity
Neurons
/ drug effects
Neuroprotection
/ drug effects
Neuroprotective Agents
/ pharmacology
Receptor, trkB
/ metabolism
Signal Transduction
/ drug effects
Alzheimer’s disease
brain-derived neurotrophic factor
flavonoids
intracellular signaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 May 2021
27 May 2021
Historique:
received:
14
04
2021
revised:
21
05
2021
accepted:
25
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
23
6
2021
Statut:
epublish
Résumé
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. A number of studies have demonstrated the possible involvement of altered expression and action of the BDNF/TrkB signaling in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). In this review, we introduce an essential role of the BDNF and its downstream signaling in neural function. We also review the current evidence on the deregulated the BDNF signaling in the pathophysiology of AD at gene, mRNA, and protein levels. Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy.
Identifiants
pubmed: 34071978
pii: ijms22115719
doi: 10.3390/ijms22115719
pmc: PMC8199014
pii:
doi:
Substances chimiques
Biomarkers
0
Brain-Derived Neurotrophic Factor
0
Flavonoids
0
Neuroprotective Agents
0
Receptor, trkB
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20K06857
Organisme : Japan Society for the Promotion of Science
ID : 19K16263
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