Diabetes, Albuminuria and the Kidney-Brain Axis.
albuminuria
chronic kidney disease
cognitive decline
dementia
diabetes
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
27 May 2021
27 May 2021
Historique:
received:
31
03
2021
revised:
19
05
2021
accepted:
24
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Cognitive decline and kidney disease are significant public health problems that share similar characteristics and risk factors. The pathophysiology of the kidney-brain axis is not completely understood, and studies analysing the relationship between the biomarkers of kidney damage and cognitive impairment show different results. This article focuses on the epidemiological and clinical aspects concerning the association of albuminuria, a marker for endothelial dysfunction and microvascular disease, and cognitive impairment in patients with chronic kidney disease, diabetic kidney disease and end-stage kidney disease. Most studies show a positive relationship between albuminuria and cognitive impairment in all groups, but evidence in type 2 diabetes (T2D) patients is limited. We briefly discuss the mechanisms underlying these associations, such as damage to the microvascular circulation, leading to hypoperfusion and blood pressure fluctuations, as well as increased inflammation and oxidative stress, both in the brain and in the kidneys. Further clinical and epidemiological studies developed to understand the interplay between the kidneys and brain diseases will hopefully lead to a reduction in cognitive impairment in these patients.
Identifiants
pubmed: 34072230
pii: jcm10112364
doi: 10.3390/jcm10112364
pmc: PMC8198842
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de salud Carlos III
ID : PI17/02222, PI19/00217
Références
J Alzheimers Dis. 2018;62(2):635-648
pubmed: 29480195
Hypertension. 2020 Jan;75(1):237-245
pubmed: 31735081
Am J Kidney Dis. 2016 Jun;67(6):841-50
pubmed: 26744126
J ASEAN Fed Endocr Soc. 2017;32(2):145-150
pubmed: 33442098
Lancet Neurol. 2019 Jul;18(7):684-696
pubmed: 31097385
Neurology. 2012 Mar 6;78(10):720-7
pubmed: 22357713
JAMA. 2019 Feb 12;321(6):553-561
pubmed: 30688979
Hypertension. 2005 Jul;46(1):200-4
pubmed: 15911742
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Cardiol Res Pract. 2011 Jan 09;2011:306189
pubmed: 21274446
Acta Neuropathol. 2015 Oct;130(4):487-99
pubmed: 26363791
Lancet Neurol. 2011 Sep;10(9):778-9
pubmed: 21775212
Curr Diab Rep. 2020 Aug 28;20(10):49
pubmed: 32857243
Front Neurosci. 2020 Jan 22;13:1452
pubmed: 32038147
Am J Kidney Dis. 2017 Nov;70(5):627-637
pubmed: 28648301
J Alzheimers Dis. 2016 Dec 6;55(3):1069-1082
pubmed: 27767995
Stroke. 2008 Jan;39(1):55-61
pubmed: 18048865
Arch Intern Med. 2011 Jan 24;171(2):142-50
pubmed: 21263104
Nature. 2010 Nov 25;468(7323):557-61
pubmed: 20944627
Am J Nephrol. 2012;35(5):474-82
pubmed: 22555151
Diabetes Care. 2020 Aug;43(8):1781-1787
pubmed: 32527799
Mol Neurobiol. 2015 Aug;52(1):115-9
pubmed: 25119777
Acta Neurol Scand. 2017 Nov;136(5):477-485
pubmed: 28261781
Cochrane Database Syst Rev. 2017 Jun 15;6:CD003804
pubmed: 28617932
BMC Geriatr. 2020 Oct 2;20(Suppl 1):297
pubmed: 33008359
Mol Neurobiol. 2016 Jul;53(5):3136-3145
pubmed: 26019016
Pharmaceuticals (Basel). 2020 Nov 11;13(11):
pubmed: 33187206
Diabetes. 2012 Dec;61(12):3063-5
pubmed: 23172953
Clin J Am Soc Nephrol. 2012 Dec;7(12):1938-46
pubmed: 23024164
Ren Fail. 2014 Sep;36(8):1258-62
pubmed: 25020185
PLoS One. 2019 Feb 15;14(2):e0212293
pubmed: 30768625
Nephrol Dial Transplant. 2009 Aug;24(8):2446-52
pubmed: 19297357
Circ J. 2020 May 25;84(6):935-942
pubmed: 32269184
Stroke Vasc Neurol. 2017 Jun 8;2(3):108-117
pubmed: 28989801
Atherosclerosis. 2017 Oct;265:71-77
pubmed: 28865325
Am J Alzheimers Dis Other Demen. 2017 Nov;32(7):444-451
pubmed: 28747063
BMJ Open. 2019 Sep 20;9(9):e030344
pubmed: 31542750
Alzheimer Dis Assoc Disord. 2015 Jul-Sep;29(3):200-5
pubmed: 25626635
Clin J Am Soc Nephrol. 2011 Jun;6(6):1400-9
pubmed: 21566108
Dement Geriatr Cogn Dis Extra. 2016 Feb 17;6(1):55-67
pubmed: 27293417
J Cereb Blood Flow Metab. 2016 Jan;36(1):55-71
pubmed: 25899297
J Alzheimers Dis. 2020;76(1):225-236
pubmed: 32444541
Can J Neurol Sci. 2016 Apr;43 Suppl 1:S3-S50
pubmed: 27307127
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Neurobiol Aging. 2018 May;65:98-108
pubmed: 29455029
Diabetologia. 2018 Mar;61(3):562-573
pubmed: 29138876
J Alzheimers Dis. 2015;47(1):167-76
pubmed: 26402765
Nat Rev Neurosci. 2011 Mar;12(3):169-82
pubmed: 21331083
Nat Rev Neurol. 2015 Aug;11(8):457-70
pubmed: 26195256
J Diabetes Complications. 2021 Mar;35(3):107805
pubmed: 33288412
Sci Rep. 2020 Sep 9;10(1):14852
pubmed: 32908199
J Alzheimers Dis. 2019;70(s1):S19-S30
pubmed: 30372677
PLoS One. 2016 Jul 06;11(7):e0158765
pubmed: 27383068
Rev Neurol. 2018 Jun 1;66(11):377-386
pubmed: 29790571
JAMA Neurol. 2014 Apr;71(4):505-8
pubmed: 24493463
Am J Nephrol. 2015;41(4-5):305-12
pubmed: 26201453
Diabetologia. 1989 Apr;32(4):219-26
pubmed: 2668076
Lancet Neurol. 2010 Jul;9(7):689-701
pubmed: 20610345
Am J Kidney Dis. 2020 Dec;76(6):775-783
pubmed: 32428540
J Am Geriatr Soc. 2017 May;65(5):966-972
pubmed: 28067945
N Engl J Med. 2017 Aug 31;377(9):839-848
pubmed: 28854085
Hypertens Res. 2009 Feb;32(2):115-21
pubmed: 19262469
Diabetes Care. 2017 Jul;40(7):958-965
pubmed: 28500216
Diabetes. 2018 Sep;67(9):1729-1741
pubmed: 30135134
J Gerontol A Biol Sci Med Sci. 2016 Jun;71(6):803-10
pubmed: 26589241
Nat Rev Neurosci. 2020 Jan;21(1):21-35
pubmed: 31780819
J Alzheimers Dis. 2018;62(3):1443-1466
pubmed: 29562545
Diabetologia. 2021 Jun;64(6):1235-1245
pubmed: 33559704
BMJ. 2010 Jul 26;341:c3666
pubmed: 20660506
J Am Geriatr Soc. 2017 Jun;65(6):1190-1198
pubmed: 28152169
Am J Kidney Dis. 2017 Jun;69(6):780-787
pubmed: 28131531
Hypertension. 2019 Feb;73(2):342-349
pubmed: 30606062
Adv Chronic Kidney Dis. 2018 Mar;25(2):121-132
pubmed: 29580576
J Am Heart Assoc. 2018 Jan 20;7(2):
pubmed: 29353232
J Neurol Neurosurg Psychiatry. 2020 Jan;91(1):88-97
pubmed: 31511306
Neurology. 2016 May 24;86(21):1996-2005
pubmed: 27164678
Hypertension. 2013 Nov;62(5):810-7
pubmed: 23980072
J Am Med Dir Assoc. 2018 Jul;19(7):601-606.e2
pubmed: 29396187
Lancet Diabetes Endocrinol. 2014 Jul;2(7):562-72
pubmed: 24898834
Clin Med (Lond). 2010 Oct;10(5):505-9
pubmed: 21117389
Science. 2010 Dec 24;330(6012):1774
pubmed: 21148344
J Diabetes. 2018 Aug;10(8):625-632
pubmed: 29380932
Am J Kidney Dis. 2019 Dec;74(6):782-790
pubmed: 31378643
Neurology. 2017 Jan 10;88(2):198-208
pubmed: 27974647
J Am Geriatr Soc. 2012 Dec;60(12):2215-22
pubmed: 23231548
BMC Nephrol. 2019 Jul 12;20(1):261
pubmed: 31299931
Neurology. 2020 Jun 16;94(24):e2581-e2591
pubmed: 32439819
Kidney Int. 2021 Mar;99(3S):S1-S87
pubmed: 33637192
J Neurol Sci. 2020 Feb 15;409:116635
pubmed: 31869590
Diabetes Care. 2013 Oct;36(10):2981-7
pubmed: 24009301
Diabetes. 2006 Jun;55(6):1832-9
pubmed: 16731850
Stroke. 2008 Jul;39(7):1952-9
pubmed: 18436879