Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
29 05 2021
Historique:
received: 23 04 2021
revised: 17 05 2021
accepted: 25 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 28 1 2022
Statut: epublish

Résumé

Non-polio enteroviruses (NPEV) and parechoviruses (PeV) are widespread pathogens that cause significant morbidity. Surveillance is based on culturing or genotyping of virus strains found in clinical samples. Sero-surveillance, by measuring neutralising antibodies (nAb) through virus neutralisation assays (VNA), could provide additional information as it offers a more comprehensive overview of exposure to circulating types in the general population. In our study we evaluated Intravenous immunoglobulins (IVIG) to generate sero-surveillance data. We performed VNA of nineteen NPEV and PeV with Dutch IVIG batches from two different time points (2010 and 2017) and an IVIG batch from Vietnam (2011). We compared our findings with geno- and sero-surveillance data and evaluated changes over time and between the two countries. Our findings show a good correlation with what is known from geno-surveillance data. The highest nAb titres were found against strains from

Identifiants

pubmed: 34072486
pii: v13061028
doi: 10.3390/v13061028
pmc: PMC8228535
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Immunoglobulins, Intravenous 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Karen Couderé (K)

Department of Medical Microbiology Microvida, Elisabeth-Tweesteden Ziekenhuis, 5022 GC Tilburg, The Netherlands.

Karlijn van der Straten (K)

Department of Medical Microbiology, Amsterdam University Medical Centres, Locatie AMC, 1105 AZ Amsterdam, The Netherlands.

Lieke Brouwer (L)

Department of Medical Microbiology, Amsterdam University Medical Centres, Locatie AMC, 1105 AZ Amsterdam, The Netherlands.

Gerrit Koen (G)

Department of Medical Microbiology, Amsterdam University Medical Centres, Locatie AMC, 1105 AZ Amsterdam, The Netherlands.

Hetty van Eijk (H)

Department of Medical Microbiology, Amsterdam University Medical Centres, Locatie AMC, 1105 AZ Amsterdam, The Netherlands.

Dasja Pajkrt (D)

Emma Children's Hospital Department of Pediatric Infectious Diseases, Amsterdam University Medical Centres, Location AMC, 1105 AZ Amsterdam, The Netherlands.

Jean-Luc Murk (JL)

Department of Medical Microbiology Microvida, Elisabeth-Tweesteden Ziekenhuis, 5022 GC Tilburg, The Netherlands.

Katja C Wolthers (KC)

Department of Medical Microbiology, Amsterdam University Medical Centres, Locatie AMC, 1105 AZ Amsterdam, The Netherlands.

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Classifications MeSH