Astrocytes in Multiple Sclerosis-Essential Constituents with Diverse Multifaceted Functions.
astrocyte activation
astrocytes
blood–brain barrier (BBB)
experimental autoimmune encephalomyelitis (EAE)
inflammation
multiple sclerosis (MS)
neuroprotection
neurotrophic factors
repair processes
tissue damage
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
10
05
2021
revised:
24
05
2021
accepted:
25
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
25
6
2021
Statut:
epublish
Résumé
In multiple sclerosis (MS), astrocytes respond to the inflammatory stimulation with an early robust process of morphological, transcriptional, biochemical, and functional remodeling. Recent studies utilizing novel technologies in samples from MS patients, and in an animal model of MS, experimental autoimmune encephalomyelitis (EAE), exposed the detrimental and the beneficial, in part contradictory, functions of this heterogeneous cell population. In this review, we summarize the various roles of astrocytes in recruiting immune cells to lesion sites, engendering the inflammatory loop, and inflicting tissue damage. The roles of astrocytes in suppressing excessive inflammation and promoting neuroprotection and repair processes is also discussed. The pivotal roles played by astrocytes make them an attractive therapeutic target. Improved understanding of astrocyte function and diversity, and the mechanisms by which they are regulated may lead to the development of novel approaches to selectively block astrocytic detrimental responses and/or enhance their protective properties.
Identifiants
pubmed: 34072790
pii: ijms22115904
doi: 10.3390/ijms22115904
pmc: PMC8198285
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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