Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy.
Ablation Techniques
Animals
Cardiomegaly
/ genetics
Chemokine CXCL12
/ genetics
Coronary Vessels
Disease Models, Animal
Gene Expression Regulation
/ genetics
Humans
Macrophages
/ metabolism
Mice
Muscle, Smooth
/ metabolism
Myocardial Infarction
/ genetics
Myocardium
/ metabolism
Receptors, CXCR
/ genetics
CXCL12
M2 macrophages
cardiac hypertrophy
coronary artery
fibrosis
remodeling
smooth muscle cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
17
04
2021
revised:
26
05
2021
accepted:
28
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
24
6
2021
Statut:
epublish
Résumé
The chemokine CXCL12 plays a fundamental role in cardiovascular development, cell trafficking, and myocardial repair. Human genome-wide association studies even have identified novel loci downstream of the CXCL12 gene locus associated with coronary artery disease and myocardial infarction. Nevertheless, cell and tissue specific effects of CXCL12 are barely understood. Since we detected high expression of CXCL12 in smooth muscle (SM) cells, we generated a SM22-alpha-Cre driven mouse model to ablate CXCL12 (SM-CXCL12
Identifiants
pubmed: 34072818
pii: ijms22115908
doi: 10.3390/ijms22115908
pmc: PMC8198701
pii:
doi:
Substances chimiques
Chemokine CXCL12
0
Cmkor1 protein, mouse
0
Cxcl12 protein, mouse
0
Receptors, CXCR
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : P 28817
Pays : Austria
Organisme : Austrian Science Fund
ID : FWF P 28817-B28
Organisme : Österreichische Forschungsförderungsgesellschaft
ID : Grant 858057
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