Characteristics of the Urinary Proteome in Women with Overactive Bladder Syndrome: A Case-Control Study.
antimicrobial
apoptosis
cellular response to stress
mass spectrometry
overactive bladder syndrome
pathophysiology
protein pathway
proteomics
urine
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
21
05
2021
revised:
28
05
2021
accepted:
29
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Despite an estimated prevalence of 13% in women, the exact etiology of non-neurogenic overactive bladder syndrome is unclear. The aim of our study was to gain a better understanding of the pathophysiology of female overactive bladder syndrome by mapping the urinary proteomic profile. We collected urine samples of 20 patients with overactive bladder syndrome and of 20 controls. We used mass spectrometric analysis for label-free quantitation, Swissprot human database for data search, Scaffold for data allocation and the Reactome Knowledgebase for final pathway enrichment analysis. We identified 1897 proteins at a false discovery rate of 1% and significance level
Identifiants
pubmed: 34072980
pii: jcm10112446
doi: 10.3390/jcm10112446
pmc: PMC8198757
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical-scientific fund of the Mayor of the federal capital Vienna
ID : 14086
Références
BJU Int. 2009 Jan;103(2):202-9
pubmed: 19278532
J Urol. 2013 Aug;190(2):757-64
pubmed: 23454160
Anal Biochem. 1984 Apr;138(1):141-3
pubmed: 6731838
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5390-E5399
pubmed: 29784788
Annu Rev Physiol. 2005;67:225-57
pubmed: 15709958
Arch Intern Med. 2005 Mar 14;165(5):537-42
pubmed: 15767530
Int Urogynecol J. 2010 Jan;21(1):5-26
pubmed: 19937315
Can Urol Assoc J. 2017 May;11(5):E142-E173
pubmed: 28503229
Int J Clin Pract. 2009 Dec;63(12):1675-82
pubmed: 19930329
Int Urol Nephrol. 2014 Feb;46(2):341-7
pubmed: 23982767
J Urol. 2013 Jan;189(1):359-65
pubmed: 23174241
Int Urogynecol J. 2016 Nov;27(11):1729-1734
pubmed: 27193112
Int Urol Nephrol. 2014 May;46(5):871-7
pubmed: 24323058
BJU Int. 2013 Mar;111(3):372-80
pubmed: 23444927
J Clin Med. 2020 May 08;9(5):
pubmed: 32397227
Bioinformatics. 2005 Jul 15;21(14):3097-104
pubmed: 15845654
Electrophoresis. 2018 Apr;39(8):1071-1078
pubmed: 29359342
Int Urogynecol J. 2013 Feb;24(2):325-30
pubmed: 22717785
BMC Fam Pract. 2009 Jan 23;10:8
pubmed: 19166611
BMC Bioinformatics. 2017 Mar 2;18(1):142
pubmed: 28249561
Anal Chem. 2009 Jul 15;81(14):5955-60
pubmed: 19537771
Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503
pubmed: 31691815
Int Urogynecol J. 2013 Jul;24(7):1065-72
pubmed: 23314226
PLoS One. 2013 Oct 01;8(10):e76706
pubmed: 24098552
Int Urogynecol J. 2013 Oct;24(10):1603-9
pubmed: 23649686
FASEB J. 2003 May;17(8):790-9
pubmed: 12724336