Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones.
angiogenesis
apoptosis
autophagy
cell cycle arrest
cell death
chalcones
signaling pathway
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
28
04
2021
revised:
20
05
2021
accepted:
27
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015-February 2021.
Identifiants
pubmed: 34073042
pii: cancers13112730
doi: 10.3390/cancers13112730
pmc: PMC8198114
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
ID : VEGA 1/0653/19
Organisme : Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
ID : VEGA 1/0539/21
Organisme : Agentúra na Podporu Výskumu a Vývoja
ID : APVV-16-0446
Organisme : European Regional Development Fund
ID : OPENMED, ITMS2014+: 313011V455
Références
Oncol Lett. 2017 Sep;14(3):2852-2858
pubmed: 28928824
Onco Targets Ther. 2019 Jun 05;12:4427-4435
pubmed: 31239711
Phytomedicine. 2015 Jul 15;22(7-8):737-43
pubmed: 26141760
Oncotarget. 2016 Apr 5;7(14):18651-64
pubmed: 26919107
Tumour Biol. 2016 Jul;37(7):8471-86
pubmed: 27059734
Oncol Lett. 2018 Nov;16(5):6615-6623
pubmed: 30344763
Int J Mol Sci. 2017 Sep 21;18(10):
pubmed: 28934130
Int J Mol Sci. 2017 Aug 12;18(8):
pubmed: 28805696
Exp Ther Med. 2016 Feb;11(2):403-408
pubmed: 26893622
Protein Cell. 2013 Mar;4(3):176-85
pubmed: 23483479
Eur J Med Chem. 2018 Apr 25;150:920-929
pubmed: 29602038
Cancer Sci. 2018 Jan;109(1):132-140
pubmed: 29121426
J Biol Chem. 2018 Jun 15;293(24):9461-9472
pubmed: 29691282
BMC Cancer. 2019 Jan 16;19(1):77
pubmed: 30651087
Onkologie. 2000 Oct;23(5):424-430
pubmed: 11441236
Asian Pac J Cancer Prev. 2019 Nov 01;20(11):3437-3446
pubmed: 31759370
Oncol Lett. 2020 Feb;19(2):1393-1399
pubmed: 32002030
J Cell Physiol. 2019 Feb;234(2):1780-1793
pubmed: 30070696
Phytother Res. 2018 Dec;32(12):2428-2435
pubmed: 30123958
Phytother Res. 2020 Aug;34(8):2032-2043
pubmed: 32144852
PLoS One. 2018 Feb 8;13(2):e0191523
pubmed: 29420562
Acta Pharmacol Sin. 2020 Jan;41(1):82-92
pubmed: 31371781
Int J Mol Sci. 2019 Aug 05;20(15):
pubmed: 31387245
Cancers (Basel). 2020 Jun 23;12(6):
pubmed: 32585896
Mol Med Rep. 2018 Sep;18(3):3429-3436
pubmed: 30066879
Acta Biochim Pol. 2020 Apr 28;67(2):181-188
pubmed: 32343512
Biomed Pharmacother. 2018 Feb;98:709-718
pubmed: 29306208
Biomed Pharmacother. 2021 Feb;134:111155
pubmed: 33370628
Biomol Ther (Seoul). 2018 May 1;26(3):328-334
pubmed: 29301388
Biomolecules. 2020 Nov 10;10(11):
pubmed: 33182828
J BUON. 2020 Jan-Feb;25(1):308-313
pubmed: 32277647
Food Chem Toxicol. 2018 Oct;120:407-417
pubmed: 30055311
Front Pharmacol. 2018 May 22;9:530
pubmed: 29872398
Drug Des Devel Ther. 2018 Apr 19;12:887-899
pubmed: 29719375
Int J Oncol. 2014 Aug;45(2):667-74
pubmed: 24858379
Phytother Res. 2017 Oct;31(10):1607-1613
pubmed: 28816367
Exp Ther Med. 2020 Apr;19(4):2989-2996
pubmed: 32256785
Nutr Rev. 2017 Nov 1;75(11):883-908
pubmed: 29025004
Cancer Res. 2017 Jun 15;77(12):3244-3254
pubmed: 28428276
Aging (Albany NY). 2020 Nov 25;12(24):25730-25743
pubmed: 33234722
Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129408
pubmed: 31386885
FEBS J. 2016 Jul;283(14):2640-52
pubmed: 26587781
Biomolecules. 2019 Sep 30;9(10):
pubmed: 31575072
J Exp Clin Cancer Res. 2018 Oct 3;37(1):243
pubmed: 30285892
Angiology. 2000 Jul;51(7):535-44
pubmed: 10917578
Drug Des Devel Ther. 2020 Oct 20;14:4363-4376
pubmed: 33116421
Anticancer Drugs. 2018 Jun;29(5):449-456
pubmed: 29649038
Cancers (Basel). 2019 Dec 07;11(12):
pubmed: 31817828
Tumour Biol. 2015 Dec;36(12):9667-76
pubmed: 26150336
Cancers (Basel). 2020 Oct 12;12(10):
pubmed: 33053749
Oncol Lett. 2018 Feb;15(2):1869-1873
pubmed: 29399197
Life Sci. 2020 Jun 1;250:117591
pubmed: 32224026
Mol Med Rep. 2016 Jul;14(1):911-9
pubmed: 27221781
PLoS One. 2015 Mar 16;10(3):e0120919
pubmed: 25775405
Aging (Albany NY). 2016 Apr;8(4):603-19
pubmed: 27019364
J Exp Clin Cancer Res. 2019 Jan 8;38(1):8
pubmed: 30621754
Front Cell Dev Biol. 2021 Jan 21;9:631623
pubmed: 33585487
Molecules. 2019 Nov 15;24(22):
pubmed: 31731596
Phytomedicine. 2015 Nov 15;22(12):1096-102
pubmed: 26547532
Cancers (Basel). 2020 Jul 20;12(7):
pubmed: 32698360
Phytomedicine. 2019 Nov;64:153068
pubmed: 31419729
J Nat Prod. 2020 May 22;83(5):1461-1472
pubmed: 32347726
Food Funct. 2018 Aug 15;9(8):4500-4507
pubmed: 30083664
Antioxidants (Basel). 2020 Mar 10;9(3):
pubmed: 32164337
Phytomedicine. 2018 Mar 15;42:199-206
pubmed: 29655687
Food Chem Toxicol. 2019 Sep;131:110550
pubmed: 31163223
Cells. 2020 Apr 10;9(4):
pubmed: 32290112
Int J Mol Sci. 2017 Dec 22;19(1):
pubmed: 29271940
Food Chem Toxicol. 2019 Sep;131:110533
pubmed: 31150783
Asian Pac J Cancer Prev. 2015;16(6):2129-44
pubmed: 25824729
Biochem J. 2018 Jan 23;475(2):373-398
pubmed: 29363591
Oncotarget. 2017 Sep 30;8(50):88069-88078
pubmed: 29152142
Phytomedicine. 2020 Apr;69:153210
pubmed: 32217447
J BUON. 2020 Jan-Feb;25(1):344-349
pubmed: 32277653
Cell Death Dis. 2020 Jul 8;11(7):517
pubmed: 32641772
Oncotarget. 2016 Nov 8;7(45):73432-73447
pubmed: 27708238
Front Pharmacol. 2018 Jul 31;9:837
pubmed: 30108506
Oncol Lett. 2017 May;13(5):3662-3668
pubmed: 28521469
Oncol Rep. 2017 Jul;38(1):575-583
pubmed: 28560439
Cancers (Basel). 2020 Sep 01;12(9):
pubmed: 32882870
Phytomedicine. 2018 Mar 15;42:144-151
pubmed: 29655680
Phytomedicine. 2018 Jan 15;39:100-110
pubmed: 29433671
Cell Biochem Funct. 2019 Apr;37(3):128-138
pubmed: 30883849
Mol Cancer Ther. 2015 Jun;14(6):1395-403
pubmed: 25887885
Nat Rev Mol Cell Biol. 2008 Dec;9(12):1004-10
pubmed: 18971948
Am J Chin Med. 2015;43(4):769-82
pubmed: 26119952
Food Funct. 2018 Dec 13;9(12):6196-6204
pubmed: 30465574
Eur J Med Chem. 2018 Jul 15;155:263-274
pubmed: 29890388
Antioxid Redox Signal. 2019 Jun 20;30(18):2110-2153
pubmed: 28398124
Recent Pat Inflamm Allergy Drug Discov. 2019;13(1):49-56
pubmed: 30457056
Int J Oncol. 2016 Apr;48(4):1749-57
pubmed: 26847145
Int Angiol. 2011 Jun;30(3):272-7
pubmed: 21617611
Molecules. 2018 Aug 13;23(8):
pubmed: 30104527
Cancer Prev Res (Phila). 2018 Oct;11(10):607-620
pubmed: 29980517
J Cancer Metastasis Treat. 2020;6:
pubmed: 33521321
J Mol Biol. 2017 Jun 2;429(11):1595-1606
pubmed: 28390900
Recent Pat Anticancer Drug Discov. 2016;11(2):215-27
pubmed: 26951491
Br J Cancer. 2015 Mar 17;112(6):957-62
pubmed: 25742467
Bioorg Med Chem. 2020 Jun 1;28(11):115527
pubmed: 32345458
Pharmacogn Mag. 2017 Jul;13(Suppl 2):S321-S328
pubmed: 28808400
Phytomedicine. 2019 Sep;62:152964
pubmed: 31153059
Int J Mol Med. 2018 May;41(5):2601-2608
pubmed: 29484365
Int J Mol Sci. 2018 Feb 02;19(2):
pubmed: 29393886
Mol Med Rep. 2016 Feb;13(2):1091-6
pubmed: 26676515
Cell Biol Toxicol. 2020 Apr;36(2):145-164
pubmed: 31820165
Molecules. 2016 Dec 28;22(1):
pubmed: 28036030
Drug Dev Res. 2019 Jun;80(4):461-470
pubmed: 30698296
Phytother Res. 2019 Dec;33(12):3242-3250
pubmed: 31489735
Front Pharmacol. 2020 Mar 31;11:378
pubmed: 32296334
Card Fail Rev. 2019 May 24;5(2):112-118
pubmed: 31179022
Genes Nutr. 2011 May;6(2):125-47
pubmed: 21484163
Chem Biol Interact. 2019 May 1;304:131-138
pubmed: 30890322
J Cell Biochem. 2018 Dec;119(12):10118-10130
pubmed: 30129052
Molecules. 2018 Feb 14;23(2):
pubmed: 29443909
Psychiatr Danub. 2017 Dec;29 Suppl 4(Suppl 4):787-792
pubmed: 29278625
Oncotarget. 2016 Aug 9;7(32):52281-52293
pubmed: 27447570
Biofactors. 2017 Mar;43(2):152-169
pubmed: 27580587
Oncol Rep. 2018 Feb;39(2):687-694
pubmed: 29251326
Cancer. 2020 May 15;126(10):2225-2249
pubmed: 32162336
Cell Biol Int. 2019 Aug 8;:
pubmed: 31393045
Transl Lung Cancer Res. 2020 Aug;9(4):1569-1584
pubmed: 32953528
Biomed Pharmacother. 2017 Jan;85:425-433
pubmed: 27903423
Oncol Rep. 2016 Apr;35(4):2065-72
pubmed: 26794001
Biomed Res Int. 2014;2014:150845
pubmed: 25013758
Oncol Rep. 2012 Sep;28(3):797-805
pubmed: 22710558
Cancer Chemother Pharmacol. 2017 Jul;80(1):1-14
pubmed: 28528358
Sci Rep. 2017 May 19;7(1):2213
pubmed: 28526832
Biomolecules. 2020 Feb 22;10(2):
pubmed: 32098428
Int J Biol Sci. 2019 Jun 4;15(8):1637-1653
pubmed: 31360107
Environ Sci Pollut Res Int. 2020 Oct;27(30):37488-37501
pubmed: 32683625
Molecules. 2019 Jul 02;24(13):
pubmed: 31269698
Phytomedicine. 2018 Feb 1;40:37-47
pubmed: 29496173
Phytother Res. 2020 Dec 9;:
pubmed: 33295678
Oncol Rep. 2019 Apr;41(4):2502-2510
pubmed: 30720124
Sci Rep. 2017 Sep 6;7(1):10729
pubmed: 28878321
Int J Biol Sci. 2019 Sep 7;15(11):2497-2508
pubmed: 31595166
BMC Complement Altern Med. 2015 Dec 22;15:445
pubmed: 26694191
PLoS One. 2015 May 26;10(5):e0127464
pubmed: 26011160
Oxid Med Cell Longev. 2018 Oct 16;2018:1915828
pubmed: 30410640
Mol Ther Methods Clin Dev. 2018 Feb 15;9:153-159
pubmed: 29766025
Nat Rev Clin Oncol. 2018 May;15(5):273-291
pubmed: 29508857
Int J Mol Med. 2020 Feb;45(2):279-297
pubmed: 31894255
APMIS. 2018 Sep;126(9):710-721
pubmed: 30058214
Cell Mol Life Sci. 2020 May;77(9):1745-1770
pubmed: 31690961
J Nutr Biochem. 2018 Apr;54:140-150
pubmed: 29414668
Pharmacol Rep. 2018 Oct;70(5):908-916
pubmed: 30099297
Oncol Rep. 2019 Jun;41(6):3355-3366
pubmed: 30942462
Oncol Rep. 2018 May;39(5):2160-2170
pubmed: 29565458
Oncol Rep. 2020 Oct;44(4):1365-1374
pubmed: 32945473
Cells. 2019 Nov 14;8(11):
pubmed: 31739642
J Pharm Biomed Anal. 2020 Jul 15;186:113288
pubmed: 32361091
Arch Toxicol. 2017 Oct;91(10):3341-3364
pubmed: 28374157
Medicines (Basel). 2018 Nov 13;5(4):
pubmed: 30428619
J Biol Chem. 2014 Dec 26;289(52):35839-48
pubmed: 25368326
Biomol Ther (Seoul). 2020 Nov 1;28(6):503-511
pubmed: 33077698
Oncol Lett. 2018 Nov;16(5):6133-6139
pubmed: 30344755
Evid Based Complement Alternat Med. 2020 Mar 16;2020:3821248
pubmed: 32256642
Phytomedicine. 2021 Jan;80:153373
pubmed: 33096451
Chem Biol Interact. 2018 Aug 25;292:37-49
pubmed: 29981726
Chem Biol Interact. 2020 Aug 25;327:109185
pubmed: 32590072
Front Pharmacol. 2018 Dec 10;9:1455
pubmed: 30618749
Antioxidants (Basel). 2019 May 18;8(5):
pubmed: 31109072
J Med Chem. 2015 Mar 12;58(5):2489-512
pubmed: 25654321
Biomed Res Int. 2019 Oct 22;2019:7298539
pubmed: 31772936
Oxid Med Cell Longev. 2017;2017:1379430
pubmed: 28203317
Cancers (Basel). 2018 Jan 12;10(1):
pubmed: 29329237
Apoptosis. 2017 Jan;22(1):158-168
pubmed: 27900636
Molecules. 2017 Mar 14;22(3):
pubmed: 28335434
Arch Hist Filoz Med. 2004;67(1):5-14
pubmed: 15586450
Cells. 2019 Oct 22;8(10):
pubmed: 31652491
Chin J Integr Med. 2012 Jul;18(7):543-7
pubmed: 22772918
Int J Mol Sci. 2020 Dec 20;21(24):
pubmed: 33419373
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Biomed Pharmacother. 2015 Jul;73:40-7
pubmed: 26211581
Am J Pathol. 2014 Jun;184(6):1630-42
pubmed: 24726643
Oncotarget. 2017 May 9;8(19):31297-31304
pubmed: 28415750
J Cancer. 2019 Feb 26;10(6):1570-1579
pubmed: 31031867
Onco Targets Ther. 2018 Apr 11;11:2063-2073
pubmed: 29695914
Nat Prod Commun. 2015 Jul;10(7):1199-202
pubmed: 26411010
Nutrients. 2020 Jun 12;12(6):
pubmed: 32545423
J Exp Clin Cancer Res. 2019 Aug 27;38(1):377
pubmed: 31455352
Int J Clin Exp Pathol. 2015 Oct 01;8(10):12577-82
pubmed: 26722447
Mol Biol Cell. 2009 Apr;20(7):1992-2003
pubmed: 19225151
Int J Mol Sci. 2020 Feb 20;21(4):
pubmed: 32093389
Phytother Res. 2020 Feb;34(2):388-400
pubmed: 31698509
Biomed Res Int. 2015;2015:549412
pubmed: 26146622
J Cell Physiol. 2019 Aug;234(10):17514-17526
pubmed: 30847898
Drug Des Devel Ther. 2019 May 01;13:1449-1460
pubmed: 31118579
Eur J Pharmacol. 2018 Feb 15;821:57-67
pubmed: 29277717
Exp Oncol. 2017 Jul;39(2):98-105
pubmed: 29483500
Mol Med Rep. 2015 Nov;12(5):7623-8
pubmed: 26397392
Biomed Pharmacother. 2018 Nov;107:957-966
pubmed: 30257408
Molecules. 2019 Nov 09;24(22):
pubmed: 31717502
Sci Rep. 2018 Sep 24;8(1):14294
pubmed: 30250282
Chem Biol Interact. 2019 Feb 1;299:77-87
pubmed: 30502331
Anticancer Drugs. 2019 Mar;30(3):241-250
pubmed: 30640793
BMC Cancer. 2021 Jan 22;21(1):91
pubmed: 33482772
Mini Rev Med Chem. 2019;19(8):647-656
pubmed: 30049263
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Phytother Res. 2017 Dec;31(12):1858-1867
pubmed: 29027311
J Photochem Photobiol B. 2017 Feb;167:299-308
pubmed: 28122297
Biomed Pharmacother. 2015 Mar;70:140-5
pubmed: 25776492
Phytomedicine. 2019 Oct;63:153014
pubmed: 31323446
J Exp Clin Cancer Res. 2019 Aug 22;38(1):371
pubmed: 31438982
Cell. 2018 Apr 5;173(2):321-337.e10
pubmed: 29625050
Drug Des Devel Ther. 2016 Jun 10;10:1897-907
pubmed: 27358555
Annu Rev Pathol. 2015;10:173-94
pubmed: 25387057
Chem Rev. 2017 Jun 28;117(12):7762-7810
pubmed: 28488435
Bioorg Med Chem Lett. 2015 Jun 15;25(12):2559-64
pubmed: 25959811
J Med Food. 2014 Jun;17(6):633-40
pubmed: 24433078
Molecules. 2019 Oct 16;24(20):
pubmed: 31623144
PLoS One. 2018 Feb 22;13(2):e0192548
pubmed: 29470507
Onco Targets Ther. 2018 Apr 06;11:2007-2015
pubmed: 29670376
Recent Pat Anticancer Drug Discov. 2016;11(4):444-452
pubmed: 27719653
Evid Based Complement Alternat Med. 2013;2013:815621
pubmed: 23690855
Arch Pharm Res. 2017 Aug;40(8):915-920
pubmed: 28508182
Autophagy. 2018;14(11):2007-2022
pubmed: 30025493
Biomed Pharmacother. 2019 Feb;110:473-481
pubmed: 30530050
Oncol Lett. 2020 Jan;19(1):379-387
pubmed: 31897150
Thorac Cancer. 2019 Jun;10(6):1319-1333
pubmed: 31055884
Phytomedicine. 2019 Aug;61:152813
pubmed: 31035049
Cancer Res. 2014 Nov 1;74(21):6236-47
pubmed: 25217526
Cancers (Basel). 2014 Dec 23;7(1):30-69
pubmed: 25545885
Phytomedicine. 2019 Jan;52:60-69
pubmed: 30599913
J BUON. 2019 Nov-Dec;24(6):2442-2447
pubmed: 31983118
Sci Rep. 2015 May 18;5:10336
pubmed: 25981581
Clin Chim Acta. 2015 Jan 1;438:139-47
pubmed: 25172038
Cell Cycle. 2018;17(7):829-832
pubmed: 29464983
Arch Pharm (Weinheim). 2020 Apr;353(4):e1900350
pubmed: 32003489
Phytother Res. 2020 Feb;34(2):349-358
pubmed: 31793097
Oncol Lett. 2018 Jan;15(1):908-916
pubmed: 29422966
Cold Spring Harb Perspect Biol. 2015 Dec 01;7(12):
pubmed: 26626938
Biomed Res Int. 2020 Dec 19;2020:4926821
pubmed: 33415148