Detection of EGFR Mutations in Plasma cfDNA and Paired CTCs of NSCLC Patients before and after Osimertinib Therapy Using Crystal Digital PCR.
EGFR mutations
circulating tumor DNA (ctDNA)
circulating tumor cells (CTC)
crystal digital PCR
liquid biopsy
osimertinib
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
05
04
2021
revised:
13
05
2021
accepted:
27
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Circulating tumor DNA (ctDNA) analysis has clinical utility in EGFR mutant NSCLC. Circulating tumor cells (CTCs) consist a unique source of information at the cellular level. Digital PCR (dPCR) is a valuable tool for accurate and valid analysis of gene mutations in liquid biopsy analysis. In the present study we detected EGFR mutations in ctDNA and paired CTCs under osimertinib therapy at two time points using crystal dPCR and the naica
Identifiants
pubmed: 34073111
pii: cancers13112736
doi: 10.3390/cancers13112736
pmc: PMC8197887
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Stavros Niarchos Foundation
ID : 16785
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