EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor.
ARF6
EFA6
axon injury
axon regeneration
integrin
microtubule dynamics
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 05 2021
26 05 2021
Historique:
received:
27
04
2021
revised:
23
05
2021
accepted:
24
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Axon regeneration after injury is a conserved biological process that involves a large number of molecular pathways, including rapid calcium influx at injury sites, retrograde injury signaling, epigenetic transition, transcriptional reprogramming, polarized transport, and cytoskeleton reorganization. Despite the numerous efforts devoted to understanding the underlying cellular and molecular mechanisms of axon regeneration, the search continues for effective target molecules for improving axon regeneration. Although there have been significant historical efforts towards characterizing pro-regenerative factors involved in axon regeneration, the pursuit of intrinsic inhibitors is relatively recent. EFA6 (exchange factor for ARF6) has been demonstrated to inhibit axon regeneration in different organisms. EFA6 inhibition could be a promising therapeutic strategy to promote axon regeneration and functional recovery after axon injury. This review summarizes the inhibitory role on axon regeneration through regulating microtubule dynamics and through affecting ARF6 (ADP-ribosylation factor 6) GTPase-mediated integrin transport.
Identifiants
pubmed: 34073530
pii: cells10061325
doi: 10.3390/cells10061325
pmc: PMC8226579
pii:
doi:
Substances chimiques
ADP-Ribosylation Factor 6
0
Guanine Nucleotide Exchange Factors
0
ADP-Ribosylation Factors
EC 3.6.5.2
ARF6 protein, human
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : 1R01AG070214-01
Pays : United States
Commentaires et corrections
Type : RetractionIn
Références
Elife. 2019 Nov 13;8:
pubmed: 31718774
Genes Dev. 2012 Jul 15;26(14):1612-25
pubmed: 22759636
Mol Biol Cell. 2014 Nov 1;25(21):3350-62
pubmed: 25187649
Nat Cell Biol. 2010 Dec;12(12):1235-41
pubmed: 21076413
Elife. 2018 Nov 21;7:
pubmed: 30461420
Nat Rev Mol Cell Biol. 2011 Jun;12(6):362-75
pubmed: 21587297
FEBS Lett. 2005 Dec 19;579(30):6834-8
pubmed: 16325184
J Cell Biol. 2007 Feb 12;176(4):497-507
pubmed: 17283182
EMBO J. 1999 Mar 15;18(6):1480-91
pubmed: 10075920
Nat Neurosci. 2010 Dec;13(12):1505-10
pubmed: 21076427
Science. 1972 Sep 22;177(4054):1104-5
pubmed: 4626639
Exp Neurol. 2008 Feb;209(2):407-16
pubmed: 17692844
Neuron. 2012 Dec 20;76(6):1091-107
pubmed: 23259946
J Biochem. 1977 Jul;82(1):303-6
pubmed: 561065
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18342-7
pubmed: 20937901
Curr Biol. 2006 Nov 7;16(21):2111-22
pubmed: 17084695
Nature. 2004 Dec 16;432(7019):822
pubmed: 15602545
J Neurosci. 2010 Sep 1;30(35):11654-69
pubmed: 20810886
Mol Biol Cell. 2010 Mar 1;21(5):767-77
pubmed: 20053676
Mol Cell Neurosci. 2011 Dec;48(4):278-87
pubmed: 21762782
Cell. 2007 May 4;129(3):499-510
pubmed: 17482544
Sci Transl Med. 2015 Aug 26;7(302):302ra134
pubmed: 26311729
Nat Commun. 2013;4:2038
pubmed: 23799397
EMBO J. 2012 Aug 1;31(15):3252-69
pubmed: 22781129
Eur J Neurosci. 2007 Feb;25(3):618-28
pubmed: 17298598
Mol Cell Neurosci. 2005 Feb;28(2):229-40
pubmed: 15691705
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3771-5
pubmed: 211505
Neuron. 2010 Jun 10;66(5):663-70
pubmed: 20547125
J Neurosci. 2010 May 19;30(20):6825-37
pubmed: 20484625
Annu Rev Cell Dev Biol. 2007;23:579-611
pubmed: 17506703
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12378-83
pubmed: 25114232
J Cell Biol. 2009 Jun 29;185(7):1159-66
pubmed: 19564401
Cell Rep. 2016 Apr 12;15(2):238-46
pubmed: 27050519
Neuron. 2003 Dec 18;40(6):1095-104
pubmed: 14687545
F1000Res. 2016 Apr 27;5:
pubmed: 27350865
Sci Signal. 2009 Aug 11;2(83):pe49
pubmed: 19671926
Cell Tissue Res. 2010 Jan;339(1):269-80
pubmed: 19693543
Trends Neurosci. 2010 Aug;33(8):362-72
pubmed: 20541813
J Neurosci. 1997 May 15;17(10):3568-79
pubmed: 9133380
J Cell Biol. 1999 Sep 6;146(5):1097-106
pubmed: 10477762
J Comp Neurol. 2004 Dec 6;480(2):162-9
pubmed: 15514929
J Cell Biol. 1983 Oct;97(4):963-73
pubmed: 6352712
J Biol Chem. 1980 Dec 25;255(24):11853-6
pubmed: 7440572
Science. 2011 Feb 18;331(6019):928-31
pubmed: 21273450
J Neurosci. 2010 Aug 11;30(32):10899-904
pubmed: 20702718
Exp Neurol. 2001 Sep;171(1):153-69
pubmed: 11520130
Science. 1981 Nov 20;214(4523):931-3
pubmed: 6171034
Eur J Neurosci. 2016 Feb;43(3):431-42
pubmed: 26332537
J Cell Biol. 2002 Jul 8;158(1):139-52
pubmed: 12105186
J Comp Neurol. 2001 Jun 25;435(2):184-93
pubmed: 11391640
J Neurosci. 2018 Jan 10;38(2):291-307
pubmed: 29167405
J Neurosci. 2004 Jul 21;24(29):6531-9
pubmed: 15269264
Nat Rev Neurosci. 2016 Oct;17(10):611-22
pubmed: 27511065
Curr Opin Neurobiol. 2018 Aug;51:60-69
pubmed: 29544200
Mol Cell Neurosci. 2003 Mar;22(3):383-95
pubmed: 12691739
J Neurosci. 2007 Aug 22;27(34):9169-80
pubmed: 17715353
Cancer Res. 2006 Feb 1;66(3):1583-90
pubmed: 16452216
J Neurosci. 2000 Jun 15;20(12):4615-26
pubmed: 10844031
Neuron. 2015 Nov 18;88(4):704-19
pubmed: 26526391
J Neurosci. 2005 Aug 31;25(35):8066-76
pubmed: 16135764
Neuron. 1988 Nov;1(9):761-72
pubmed: 3078414
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15132-7
pubmed: 17848506
Elife. 2016 Jan 05;5:
pubmed: 26731518
J Cell Biol. 2008 Oct 6;183(1):143-55
pubmed: 18838556
J Biol Chem. 2008 Jul 11;283(28):19836-44
pubmed: 18490450
J Comp Neurol. 2000 Dec 11;428(2):294-304
pubmed: 11064368
J Exp Biol. 1981 Dec;95:231-40
pubmed: 7334319
Elife. 2015 Sep 04;4:
pubmed: 26339988
Int Rev Neurobiol. 2013;108:257-75
pubmed: 24083438
J Cell Biol. 2008 Feb 11;180(3):619-32
pubmed: 18268107
J Neurosci. 2010 Mar 3;30(9):3175-83
pubmed: 20203177
eNeuro. 2016 Jul 27;3(4):
pubmed: 27570822
J Neurochem. 2005 May;93(3):674-85
pubmed: 15836626
Neuron. 2011 Sep 22;71(6):1043-57
pubmed: 21943602
Brain Res. 2006 Jun 6;1093(1):1-11
pubmed: 16707115
Biochem Biophys Res Commun. 1981 Oct 15;102(3):924-31
pubmed: 7306197
Nat Rev Neurosci. 2012 Feb 15;13(3):183-93
pubmed: 22334213
J Neurosci. 2000 Mar 1;20(5):1822-30
pubmed: 10684883
Ann Neurol. 2005 Oct;58(4):594-604
pubmed: 16178029
Neural Plast. 2016;2016:6808293
pubmed: 27493806
FEBS Lett. 1976 Jun 1;65(2):144-7
pubmed: 1278415
Exp Neurol. 2004 Apr;186(2):124-33
pubmed: 15026251
Neuron. 1999 May;23(1):83-91
pubmed: 10402195
J Cell Biol. 2003 Apr 14;161(1):21-6
pubmed: 12695495
Dev Cell. 2012 Oct 16;23(4):716-28
pubmed: 23000142
J Cell Biol. 1998 Nov 16;143(4):1077-86
pubmed: 9817763
Nat Rev Neurosci. 2014 Jan;15(1):32-42
pubmed: 24326686
Annu Rev Cell Dev Biol. 1997;13:83-117
pubmed: 9442869
Biol Rev Camb Philos Soc. 2018 Aug;93(3):1339-1362
pubmed: 29446228
J Neurosci. 1997 Jan 15;17(2):646-58
pubmed: 8987787
Curr Opin Neurobiol. 2017 Feb;42:118-127
pubmed: 28039763
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2337-42
pubmed: 24469796
J Cell Sci. 2002 Jul 15;115(Pt 14):2867-79
pubmed: 12082148
Mol Cell Neurosci. 2011 Jan;46(1):9-20
pubmed: 20817096
Cell. 2009 Mar 20;136(6):1148-60
pubmed: 19268344
J Cell Biol. 1986 Nov;103(5):1921-31
pubmed: 3782290
Arch Neurol. 1973 Jul;29(1):53-5
pubmed: 4711805
Exp Neurol. 1995 Jul;134(1):102-11
pubmed: 7672031
J Comp Neurol. 1999 Aug 16;411(1):162-78
pubmed: 10404114
Development. 2013 May;140(10):2082-92
pubmed: 23578932
J Neurosci. 2015 May 27;35(21):8359-75
pubmed: 26019348
Neuron. 2016 May 4;90(3):437-51
pubmed: 27151637
Mol Biol Cell. 2004 Jan;15(1):111-20
pubmed: 14565977
J Neurosci. 2011 Feb 16;31(7):2688-99
pubmed: 21325537
Neuron. 2003 Oct 9;40(2):209-27
pubmed: 14556705
Nat Neurosci. 2009 May;12(5):568-76
pubmed: 19377470
Nat Rev Neurosci. 2018 Jun;19(6):323-337
pubmed: 29666508
Science. 2015 Apr 17;348(6232):347-52
pubmed: 25765066
J Neurosci. 2012 Jul 25;32(30):10352-64
pubmed: 22836268
Front Cell Neurosci. 2016 Mar 31;10:88
pubmed: 27065809
Neuron. 2002 Jun 13;34(6):895-903
pubmed: 12086638
Nature. 1984 Jun 28-Jul 4;309(5971):791-3
pubmed: 6204205
Neuron. 2015 Aug 5;87(3):492-506
pubmed: 26247859
eNeuro. 2016 Aug 29;3(4):
pubmed: 27622210
Curr Biol. 2004 Jul 13;14(13):1194-9
pubmed: 15242617
J Comp Neurol. 2006 Feb 10;494(5):705-20
pubmed: 16374810
J Cell Sci. 2017 Nov 1;130(21):3663-3675
pubmed: 28935671
J Cell Biol. 1988 Oct;107(4):1505-16
pubmed: 3170637
Traffic. 2004 Jan;5(1):20-36
pubmed: 14675422
Cytoskeleton (Hoboken). 2016 Sep;73(9):442-60
pubmed: 26887570