OTULIN in NF-κB signaling, cell death, and disease.

Animals Cell Death Endopeptidases / metabolism Mice NF-kappa B / metabolism Signal Transduction Ubiquitin

Journal

Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032

Informations de publication

Date de publication:
07 2021
Historique:
received: 04 03 2021
revised: 03 05 2021
accepted: 05 05 2021
pubmed: 3 6 2021
medline: 6 7 2021
entrez: 2 6 2021
Statut: ppublish

Résumé

Tight control of inflammatory signaling pathways is an absolute requirement to avoid chronic inflammation and disease. One of the proteins responsible for such control is OTU deubiquitinase with linear linkage specificity (OTULIN), the only mammalian deubiquitinating enzyme (DUB) exclusively hydrolyzing linear ubiquitin chains from proteins modified by the linear ubiquitin chain assembly complex (LUBAC) described thus far. Recent findings show that loss-of-function mutations in OTULIN underlie a severe early-onset human autoinflammatory disease and severe pathology in experimental mouse models. Here, we review the molecular and cellular mechanisms by which OTULIN controls inflammation and discuss the involvement of OTULIN in inflammatory disease development. We also highlight several newly identified roles for OTULIN, including a ubiquitin-independent function.

Identifiants

DOI: 10.1016/j.it.2021.05.003 PMID: 34074601
pubmed: 34074601
pii: S1471-4906(21)00098-3
doi: 10.1016/j.it.2021.05.003
pii:
doi:

Substances chimiques

NF-kappa B 0
Ubiquitin 0
Endopeptidases EC 3.4.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

590-603

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests None declared by authors.

Auteurs

Lien Verboom (L)

VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium.

Esther Hoste (E)

VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium.

Geert van Loo (G)

VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium. Electronic address: geert.vanloo@irc.vib-ugent.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › OTULIN in NF-κB signaling, cell death, and disease.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › OTULIN in NF-κB signaling, cell death, and disease.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › OTULIN in NF-κB signaling, cell death, and disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › OTULIN in NF-κB signaling, cell death, and disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › OTULIN in NF-κB signaling, cell death, and disease.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › OTULIN in NF-κB signaling, cell death, and disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ubiquitines › Ubiquitine › OTULIN in NF-κB signaling, cell death, and disease.