Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
Journal
ACS central science
ISSN: 2374-7943
Titre abrégé: ACS Cent Sci
Pays: United States
ID NLM: 101660035
Informations de publication
Date de publication:
26 May 2021
26 May 2021
Historique:
received:
03
09
2020
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
ppublish
Résumé
The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global threat to human health. Using a multidisciplinary approach, we identified and validated the hepatitis C virus (HCV) protease inhibitor simeprevir as an especially promising repurposable drug for treating COVID-19. Simeprevir potently reduces SARS-CoV-2 viral load by multiple orders of magnitude and synergizes with remdesivir
Identifiants
pubmed: 34075346
doi: 10.1021/acscentsci.0c01186
pmc: PMC8056950
doi:
Types de publication
Journal Article
Langues
eng
Pagination
792-802Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): CUHK and HKU have filed a US provisional patent application based on the finding of this manuscript. W.L.N., M.C.W.C., K.P.Y.H., H.S.L., K.S.K., H.K., and H.-M.L. are inventors of the patent. F.K.L.C. has served as a consultant to Eisai, Pfizer, Takeda, and Otsuka and has been paid lecture fees by Eisai, Pfizer, AstraZeneca, and Takeda.
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