Profiles of Volatile Biomarkers Detect Tuberculosis from Skin.
diagnosis
noninvasive approach
point-of-care test
sensor
skin
tuberculosis
wearable device
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
19
03
2021
received:
20
01
2021
pubmed:
3
6
2021
medline:
18
1
2022
entrez:
2
6
2021
Statut:
ppublish
Résumé
Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource-limited settings. According to the World Health Organization (WHO), a rapid, sputum-free, and cost-effective triage test for real-time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB-specific volatile organic compounds (VOCs) that are detected and quantified from the skin headspace. A specifically designed nanomaterial-based sensors array translates these findings into a point-of-care diagnosis by discriminating between active pulmonary TB patients and controls with sensitivity above 90%. This fulfills the WHO's triage test requirements and poses the potential to become a TB triage test.
Identifiants
pubmed: 34075714
doi: 10.1002/advs.202100235
pmc: PMC8336503
doi:
Substances chimiques
Biomarkers
0
Volatile Organic Compounds
0
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100235Subventions
Organisme : Ariane de Rothschild Foundation
Organisme : H2020 Industrial Leadership
ID : 824270
Organisme : Bill and Melinda Gates Foundation
ID : OPP1109493
Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.
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