Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice.

Adaptive Immunity Animals Arthroplasty, Replacement, Knee Lymph Nodes Mice Signal Transduction Transforming Growth Factor beta
ARTHROFIBROSIS CYTOKINES INJURY/FRACTURE HEALING OSTEOIMMUNOLOGY

Journal

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640

Informations de publication

Date de publication:
09 2021
Historique:
revised: 21 05 2021
received: 05 11 2020
accepted: 23 05 2021
pubmed: 3 6 2021
medline: 6 1 2022
entrez: 2 6 2021
Statut: ppublish

Résumé

The importance of a local tissue immune response in healing injured tissues such as skin and lung is well established. Little is known about whether sterile wounds elicit lymph node (LN) responses and inflammatory responses after injury of musculoskeletal tissues that are mechanically loaded during the repair response. We investigated LN and tissue immune responses in a tibial implant model of joint replacement surgery where wounded tissue is subjected to movement and mechanical loading postoperatively. Draining inguinal and iliac LNs expanded postoperatively, including increases in regulatory T cells and activation of a subset of T cells. Thus, tissue injury was actively sensed in secondary lymphoid organs, with the potential to activate adaptive immunity. Joint tissues exhibited three temporally distinct immune response components, including a novel interferon (IFN) response with activation of signal transducer and activator of transcription (STAT) and interferon regulatory factor (IRF) pathways. Fibrovascular tissue formation was not associated with a macrophage type 2 (M2) reparative immune response, but instead with delayed induction of interleukin-1 family (IL-1β, IL-33, IL-36), IL-17, and prostaglandin pathway genes concomitant with transforming growth factor (TGF)-β and growth factor signaling, fibroblast activation, and tissue formation. Tissue remodeling was associated with activity of the HOX antisense intergenic RNA (HOTAIR) pathway. These results provide insights into immune responses and regulation of tissue healing after knee arthroplasty that potentially can be used to develop therapeutic strategies to improve healing, prevent arthrofibrosis, and improve surgical outcomes. © 2021 American Society for Bone and Mineral Research (ASBMR).

Identifiants

DOI: 10.1002/jbmr.4381 PMID: 34076292 PMC: PMC8727029
pubmed: 34076292
doi: 10.1002/jbmr.4381
pmc: PMC8727029
mid: NIHMS1766279
doi:

Substances chimiques

Transforming Growth Factor beta 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1765-1780

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI044938
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR050401
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE019420
Pays : United States

Informations de copyright

© 2021 American Society for Bone and Mineral Research (ASBMR).

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Auteurs

Yunwei Xia (Y)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.

Upneet K Sokhi (UK)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.
ORCID: 0000-0001-5907-5646

Richard D Bell (RD)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.

Tania Pannellini (T)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
Department of Pathology, Hospital for Special Surgery, New York, New York, USA.

Kathleen Turajane (K)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
Arthroplasty Research Laboratory, Hospital for Special Surgery, New York, New York, USA.

Yingzhen Niu (Y)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
Arthroplasty Research Laboratory, Hospital for Special Surgery, New York, New York, USA.

Laura Frye (L)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.

Max Chao (M)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.

Ugur Ayturk (U)

Research Institute, Hospital for Special Surgery, New York, New York, USA.

Miguel Otero (M)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.
Department of Orthopaedics, Weill Cornell Medicine, New York, New York, USA.

Mathias Bostrom (M)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
Arthroplasty Research Laboratory, Hospital for Special Surgery, New York, New York, USA.
Department of Orthopaedics, Weill Cornell Medicine, New York, New York, USA.

David Oliver (D)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.

Xu Yang (X)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
Arthroplasty Research Laboratory, Hospital for Special Surgery, New York, New York, USA.
ORCID: 0000-0001-8377-077X

Lionel B Ivashkiv (LB)

Research Institute, Hospital for Special Surgery, New York, New York, USA.
David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.
Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immune and repair responses in joint tissues...
questionsmedicales.fr › Eucaryotes › Animaux › Immune and repair responses in joint tissues...
questionsmedicales.fr › Procédures de chirurgie opératoire › Implantation de prothèse › Arthroplastie prothétique › Arthroplastie prothétique de genou › Immune and repair responses in joint tissues...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Immune and repair responses in joint tissues...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Immune and repair responses in joint tissues...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Immune and repair responses in joint tissues...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Immune and repair responses in joint tissues...