Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus.
Animals
Anti-Inflammatory Agents
/ pharmacology
Antihypertensive Agents
/ pharmacology
Antioxidants
/ pharmacology
Apigenin
/ pharmacology
Arterial Pressure
/ drug effects
Cardiomegaly
/ drug therapy
Cytokines
/ metabolism
Disease Models, Animal
Fibrosis
Hypertension
/ drug therapy
Male
Myocardium
/ metabolism
NADPH Oxidases
/ genetics
Oxidative Stress
/ drug effects
Paraventricular Hypothalamic Nucleus
/ drug effects
Rats, Inbred SHR
Rats, Inbred WKY
Reactive Oxygen Species
/ metabolism
Ventricular Function, Left
/ drug effects
Ventricular Remodeling
/ drug effects
Apigenin
Cytokines
Hypertension
Hypothalamic paraventricular nucleus
Oxidative stress
Journal
Cardiovascular toxicology
ISSN: 1559-0259
Titre abrégé: Cardiovasc Toxicol
Pays: United States
ID NLM: 101135818
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
08
02
2021
accepted:
17
05
2021
pubmed:
3
6
2021
medline:
8
2
2022
entrez:
2
6
2021
Statut:
ppublish
Résumé
Apigenin, identified as 4', 5, 7-trihydroxyflavone, is a natural flavonoid compound that has many interesting pharmacological activities and nutraceutical potential including anti-inflammatory and antioxidant functions. Chronic, low-grade inflammation and oxidative stress are involved in both the initiation and progression of hypertension and hypertension-induced cardiac hypertrophy. However, whether or not apigenin improves hypertension and cardiac hypertrophy through modulating NADPH oxidase-dependent reactive oxygen species (ROS) generation and inflammation in hypothalamic paraventricular nucleus (PVN) has not been reported. This study aimed to investigate the effects of apigenin on hypertension in spontaneously hypertensive rats (SHRs) and its possible central mechanism of action. SHRs and Wistar-Kyoto (WKY) rats were randomly assigned and treated with bilateral PVN infusion of apigenin or vehicle (artificial cerebrospinal fluid) via osmotic minipumps (20 μg/h) for 4 weeks. The results showed that after PVN infusion of apigenin, the mean arterial pressure (MAP), heart rate, plasma norepinephrine (NE), Beta 1 receptor in kidneys, level of phosphorylation of PKA in the ventricular tissue and cardiac hypertrophy, perivascular fibrosis, heart level of oxidative stress, PVN levels of oxidative stress, interleukin 1β (IL-1β), interleukin 6 (IL-6), iNOS, monocyte chemotactic protein 1 (MCP-1), tyrosine hydroxylase (TH), NOX2 and NOX4 were attenuated and PVN levels of interleukin 10 (IL-10), superoxide dismutase 1 (Cu/Zn-SOD) and the 67-kDa isoform of glutamate decarboxylase (GAD67) were increased. These results revealed that apigenin improves hypertension and cardiac hypertrophy in SHRs which are associated with the down-regulation of NADPH oxidase-dependent ROS generation and inflammation in the PVN.
Identifiants
pubmed: 34076830
doi: 10.1007/s12012-021-09662-1
pii: 10.1007/s12012-021-09662-1
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antihypertensive Agents
0
Antioxidants
0
Cytokines
0
Reactive Oxygen Species
0
Apigenin
7V515PI7F6
NADPH Oxidases
EC 1.6.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
721-736Subventions
Organisme : National Natural Science Foundation of China
ID : 81770426
Organisme : National Natural Science Foundation of China
ID : 82070439
Organisme : National Natural Science Foundation of China
ID : 82070440
Organisme : the Fundamental Research Funds for the Central Universities
ID : xjh012019059
Organisme : the Fundamental Research Funds for the Central Universities
ID : xzd012019035
Organisme : the Fundamental Research Funds for the Central Universities
ID : PY3A044
Organisme : Postdoctoral Research Foundation of China (CN)
ID : 2019M663750
Organisme : Natural Science Basic Research Program of Shaanxi
ID : 2020JM-079
Organisme : Natural Science Basic Research Program of Shaanxi
ID : 2019JQ-605
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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