Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper (

Amino Acid Sequence Animals Anti-Bacterial Agents / chemistry Antimicrobial Peptides / chemistry Antiprotozoal Agents / chemistry Bothrops Cathelicidins Cells, Cultured Leishmania / drug effects Macrophages Mice, Inbred BALB C Microbial Sensitivity Tests Snake Venoms / chemistry South America

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
25 06 2021
Historique:
pubmed: 3 6 2021
medline: 15 12 2021
entrez: 2 6 2021
Statut: ppublish

Résumé

Snake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (

Identifiants

DOI: 10.1021/acs.jnatprod.1c00153 PMID: 34077221
pubmed: 34077221
doi: 10.1021/acs.jnatprod.1c00153
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antimicrobial Peptides 0
Antiprotozoal Agents 0
Cathelicidins 0
Snake Venoms 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1787-1798

Auteurs

Anderson Dematei (A)

Center for Tropical Medicine, NMT, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.
Research Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.

João B Nunes (JB)

Research Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.
Laboratory for the Synthesis and Analysis of Biomolecules, LSAB, Institute of Chemistry, University of Brasilia, Brasília 70910-900, Brazil.

Daniel C Moreira (DC)

Research Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.
ORCID: 0000-0003-1961-7281

Jéssica A Jesus (JA)

Institute of Biosciences, São Paulo State University, São Paulo, Brazil.

Márcia D Laurenti (MD)

Department of Pathology, Laboratory of Pathology of Infectious Diseases, Faculty of Medicine, University of São Paulo, São Paulo 05508-060, Brazil.

Ana C A Mengarda (ACA)

Research Center on Neglected Diseases, NPDN, University of Guarulhos, Guarulhos 07023-070, Brazil.

Maria Silva Vieira (MS)

I3S, Institute of Research and Innovation in Health, University of Porto, Porto 4099-002, Portugal.
IBMC, Institute of Molecular and Cellular Biology, University of Porto, Porto 4099-002, Portugal.

Constança Pais do Amaral (CP)

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.

Marco M Domingues (MM)

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.

Josué de Moraes (J)

Research Center on Neglected Diseases, NPDN, University of Guarulhos, Guarulhos 07023-070, Brazil.
ORCID: 0000-0003-1766-7031

Luiz F D Passero (LFD)

Institute of Biosciences, São Paulo State University, São Paulo, Brazil.
Department of Pathology, Laboratory of Pathology of Infectious Diseases, Faculty of Medicine, University of São Paulo, São Paulo 05508-060, Brazil.

Guilherme Brand (G)

Laboratory for the Synthesis and Analysis of Biomolecules, LSAB, Institute of Chemistry, University of Brasilia, Brasília 70910-900, Brazil.
ORCID: 0000-0002-1615-0009

Lucinda J Bessa (LJ)

LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences of the University of Porto, Porto 4099-002, Portugal.

Reinhard Wimmer (R)

Department of Chemistry and Bioscience, Aalborg University, Aalborg 9220, Denmark.
ORCID: 0000-0001-6942-5056

Selma A S Kuckelhaus (SAS)

Research Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.

Ana M Tomás (AM)

I3S, Institute of Research and Innovation in Health, University of Porto, Porto 4099-002, Portugal.
IBMC, Institute of Molecular and Cellular Biology, University of Porto, Porto 4099-002, Portugal.
ICBAS, Abel Salazar Institute for Biomedical Research, University of Porto, Porto 4099-002, Portugal.

Nuno C Santos (NC)

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.

Alexandra Plácido (A)

LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences of the University of Porto, Porto 4099-002, Portugal.

Peter Eaton (P)

LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences of the University of Porto, Porto 4099-002, Portugal.
The Bridge, Joseph Banks Laboratories, School of Chemistry, University of Lincoln, Lincoln LN6 7TS, U.K.

José Roberto S A Leite (JRSA)

Center for Tropical Medicine, NMT, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.
Research Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.
ORCID: 0000-0002-1096-3236

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Eucaryotes › Animaux › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides antimicrobiens › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Reptiles › Serpents › Alethinophidia › Viperidae › Crotalinae › Bothrops › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Cathélicidines › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Cellules › Cellules cultivées › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de serpent › Mechanistic Insights into the Leishmanicidal...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Sud › Mechanistic Insights into the Leishmanicidal...