Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients.
Adult
Aged
Biomarkers
/ blood
Blood Platelets
/ pathology
COVID-19
/ blood
Case-Control Studies
Citrullination
Extracellular Traps
/ metabolism
Extracellular Vesicles
/ pathology
Female
Histones
/ blood
Humans
Male
Middle Aged
Pandemics
SARS-CoV-2
Severity of Illness Index
Thromboinflammation
/ blood
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
aheadofprint:
02
06
2021
pubmed:
3
6
2021
medline:
21
1
2022
entrez:
2
6
2021
Statut:
ppublish
Résumé
Pulmonary thrombus formation is a hallmark of coronavirus disease 2019 (COVID-19). A dysregulated immune response culminating in thromboinflammation has been described, but the pathomechanisms remain unclear. We studied 41 adult COVID-19 patients with positive results on reverse-transcriptase polymerase-chain-reaction assays and 37 sex- and age-matched healthy controls. Number and surface characteristics of extracellular vesicles (EVs) and citrullinated histone H3 levels were determined in plasma upon inclusion by flow cytometry and immunoassay. In total, 20 patients had severe and 21 nonsevere disease. The number of EV (median [25th, 75th percentile]) was significantly higher in patients compared with controls (658.8 [353.2, 876.6] vs. 435.5 [332.5, 585.3], geometric mean ratio [95% confidence intervals]: 2.6 [1.9, 3.6]; EV and citrullinated histone H3 are associated with COVID-19 and could provide information regarding pathophysiology of the disease.
Substances chimiques
Biomarkers
0
Histones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-122Subventions
Organisme : COVID041
ID : Medizinisch-Wissenschaftliche Fonds des Bürgermeisters der Bundeshauptstadt Wien
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.