Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Aged
Aged, 80 and over
Bayes Theorem
Brain Mapping
Brain Stem
/ blood supply
Cerebral Revascularization
/ methods
Cohort Studies
Female
Humans
Image Processing, Computer-Assisted
Ischemic Stroke
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Risk Factors
Sensorimotor Cortex
/ blood supply
Severity of Illness Index
Sex Factors
Thalamus
/ blood supply
Treatment Outcome
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 06 2021
02 06 2021
Historique:
received:
08
10
2020
accepted:
30
04
2021
entrez:
3
6
2021
pubmed:
4
6
2021
medline:
12
6
2021
Statut:
epublish
Résumé
Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.
Identifiants
pubmed: 34078897
doi: 10.1038/s41467-021-23492-3
pii: 10.1038/s41467-021-23492-3
pmc: PMC8172535
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3289Subventions
Organisme : NINDS NIH HHS
ID : R01 NS082285
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103824
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS117643
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086905
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG068563
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS115388
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114045
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100417
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS110772
Pays : United States
Organisme : BLRD VA
ID : I01 BX004672
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS100699
Pays : United States
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