Inactivation and sensitization of Pseudomonas aeruginosa by microplasma jet array for treating otitis media.

Animals Biomarkers Disease Models, Animal Microbial Sensitivity Tests / instrumentation Otitis Media / diagnosis Plasma Gases / administration & dosage Pseudomonas Infections / diagnosis Pseudomonas aeruginosa / drug effects Rats Tomography, Optical Coherence

Journal

NPJ biofilms and microbiomes
ISSN: 2055-5008
Titre abrégé: NPJ Biofilms Microbiomes
Pays: United States
ID NLM: 101666944

Informations de publication

Date de publication:
02 06 2021
Historique:
received: 18 12 2020
accepted: 28 04 2021
entrez: 3 6 2021
pubmed: 4 6 2021
medline: 11 8 2021
Statut: epublish

Résumé

Otitis media (OM), known as a middle ear infection, is the leading cause of antibiotic prescriptions for children. With wide-spread use of antibiotics in OM, resistance to antibiotics continues to decrease the efficacy of the treatment. Furthermore, as the presence of a middle ear biofilm has contributed to this reduced susceptibility to antimicrobials, effective interventions are necessary. A miniaturized 3D-printed microplasma jet array has been developed to inactivate Pseudomonas aeruginosa, a common bacterial strain associated with OM. The experiments demonstrate the disruption of planktonic and biofilm P. aeruginosa by long-lived molecular species generated by microplasma, as well as the synergy of combining microplasma treatment with antibiotic therapy. In addition, a middle ear phantom model was developed with an excised rat eardrum to investigate the antimicrobial effects of microplasma on bacteria located behind the eardrum, as in a patient-relevant setup. These results suggest the potential for microplasma as a new treatment paradigm for OM.

Identifiants

DOI: 10.1038/s41522-021-00219-2 PMID: 34078901 PMC: PMC8172902
pubmed: 34078901
doi: 10.1038/s41522-021-00219-2
pii: 10.1038/s41522-021-00219-2
pmc: PMC8172902
doi:

Substances chimiques

Biomarkers 0
Plasma Gases 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

48

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB013723
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB028615
Pays : United States

Références

Nat Protoc. 2008;3(9):1494-500
pubmed: 18772877
PLoS One. 2012;7(4):e36226
pubmed: 22558393
Arch Otolaryngol Head Neck Surg. 1999 Jan;125(1):12-8
pubmed: 9932581
Biomed Opt Express. 2019 Jan 14;10(2):539-551
pubmed: 30800498
Pediatrics. 2013 Mar;131(3):e964-99
pubmed: 23439909
Nat Rev Dis Primers. 2016 Sep 08;2:16063
pubmed: 27604644
Otolaryngol Head Neck Surg. 2018 Jul;159(1):117-126
pubmed: 29587128
Auris Nasus Larynx. 2019 Apr;46(2):294-301
pubmed: 30098846
Int J Pediatr Otorhinolaryngol. 2015 Mar;79(3):296-300
pubmed: 25623134
Lancet. 2004 Feb 7;363(9407):465-73
pubmed: 14962529
Clin Pharmacol Ther. 2007 Aug;82(2):204-9
pubmed: 17538551
Sci Rep. 2021 Mar 4;11(1):5176
pubmed: 33664323
Sci Rep. 2018 Feb 5;8(1):2422
pubmed: 29403058
JAMA. 2006 Jul 12;296(2):202-11
pubmed: 16835426
Cochrane Database Syst Rev. 2013 Jan 31;(1):CD000219
pubmed: 23440776
J Tissue Eng Regen Med. 2016 Apr;10(4):348-57
pubmed: 26227832
Biol Chem. 2018 Dec 19;400(1):3-17
pubmed: 30044756
Int Wound J. 2019 Feb;16(1):103-111
pubmed: 30311743
PLoS One. 2012;7(4):e34610
pubmed: 22558091
J Infect Dis. 1972 Dec;126(6):629-35
pubmed: 4577424
Nat Rev Microbiol. 2004 Feb;2(2):95-108
pubmed: 15040259
Am Fam Physician. 2000 Apr 15;61(8):2410-6
pubmed: 10794582
J Assoc Res Otolaryngol. 2013 Aug;14(4):483-94
pubmed: 23673509
Am J Ophthalmol. 2018 Jun;190:150-163
pubmed: 29580975
J Biophotonics. 2021 Apr;14(4):e202000215
pubmed: 33439538
Nat Rev Microbiol. 2016 Aug 11;14(9):563-75
pubmed: 27510863
Pediatrics. 2017 Jun;139(6):
pubmed: 28562283
Proc R Soc Lond B Biol Sci. 1968 Nov 5;171(1023):175-99
pubmed: 4386842
Pediatrics. 2000 Jun;105(6):E72
pubmed: 10835085
J Biomed Opt. 2017 Dec;22(12):1-11
pubmed: 29275547
Int J Antimicrob Agents. 2016 Jun;47(6):446-50
pubmed: 27179816
NPJ Biofilms Microbiomes. 2018 Oct 18;4:24
pubmed: 30374407
Vital Health Stat 13. 1998 May;(137):1-23
pubmed: 9631643
Am Fam Physician. 2018 Jun 15;97(12):Online
pubmed: 30216004
Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):271-4
pubmed: 20044147
PLoS One. 2012;7(7):e40629
pubmed: 22808213
Laryngoscope. 2015 Aug;125(8):E276-82
pubmed: 25599652
J Biomed Opt. 2010 Jul-Aug;15(4):046012
pubmed: 20799814
ISME J. 2018 Mar;12(3):669-680
pubmed: 29367665
Ann Clin Microbiol Antimicrob. 2020 Aug 19;19(1):37
pubmed: 32814573

Auteurs

Peter P Sun (PP)

Department of Civil and Environmental Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
N. Holonyak, Jr. Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
ORCID: 0000-0001-5681-6621

Jungeun Won (J)

Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
ORCID: 0000-0003-1007-4049

Gabrielle Choo-Kang (G)

Department of Civil and Environmental Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.

Shouyan Li (S)

Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.

Wenyuan Chen (W)

Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.

Guillermo L Monroy (GL)

Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
ORCID: 0000-0002-3669-8514

Eric J Chaney (EJ)

Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA.

Stephen A Boppart (SA)

Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA. boppart@illinois.edu.
Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA. boppart@illinois.edu.
Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA. boppart@illinois.edu.
Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Champaign, IL, USA. boppart@illinois.edu.
ORCID: 0000-0002-9386-5630

J Gary Eden (JG)

N. Holonyak, Jr. Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL, USA. jgeden@illinois.edu.
Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA. jgeden@illinois.edu.
ORCID: 0000-0002-3470-9793

Thanh H Nguyen (TH)

Department of Civil and Environmental Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA. thn@illinois.edu.
Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Champaign, IL, USA. thn@illinois.edu.
Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA. thn@illinois.edu.
ORCID: 0000-0002-5461-5233

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies des oreilles › Otite › Otite moyenne › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Gaz plasmas › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Pseudomonas › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Inactivation and sensitization of Pseudomonas...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Inactivation and sensitization of Pseudomonas...