Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers.
Climbers
Genotype
MCT1
Sports climbing
T1470A polymorphism
Journal
Biology of sport
ISSN: 0860-021X
Titre abrégé: Biol Sport
Pays: Poland
ID NLM: 8700872
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
21
04
2020
revised:
13
06
2020
accepted:
04
08
2020
entrez:
3
6
2021
pubmed:
4
6
2021
medline:
4
6
2021
Statut:
ppublish
Résumé
Sport climbing will become an official event at the 2020 Tokyo Olympics; it is a popular wilderness sport among athletes and amateurs. Our previous study suggested that the T1470A polymorphism (rs1049434) of the monocarboxylate transporter 1 (MCT1) gene is associated with athletic performance and physiological phenotypes. The purpose of this study was to investigate the frequency of MCT1 T1470A polymorphism in Polish and Japanese climbers using a case-control study. Our sample consisted of 226 climbers (Japanese: n = 100, 64 male and 36 female; Polish: n = 126, 97 male and 29 female) and 1028 non-athletic controls (Japanese, n = 407; Polish = 621) who were genotyped for the MCT1 T1470A polymorphism (rs1049434) using the TaqMan SNP genotyping assay or restriction enzyme. The frequency of the TT genotype and T allele was significantly higher in climbers than in controls among the Polish subjects (genotype: p = 0.030, allele: p = 0.010); however, there were no significant differences in the genotype and allelic frequencies between the Japanese climbers and controls (genotype: p = 0.968; allele: p = 0.803). Our results suggested that the frequency of the T allele (TT+TA genotype) in the MCT1 T1470A polymorphism is over-represented in Polish climbers but not in Japanese climbers. In addition, the frequency of the T allele and TT genotype in Polish lead climbers is higher than that in controls.
Identifiants
pubmed: 34079167
doi: 10.5114/biolsport.2020.98624
pii: 98624
pmc: PMC8139354
doi:
Types de publication
Journal Article
Langues
eng
Pagination
229-234Informations de copyright
Copyright © Biology of Sport 2021.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
Références
Br J Sports Med. 1997 Sep;31(3):224-8
pubmed: 9298558
Nucleic Acids Res. 2014 Jan;42(Database issue):D903-9
pubmed: 24275494
Int J Sports Med. 2017 Jan;38(1):76-80
pubmed: 27813046
J Strength Cond Res. 2017 Apr;31(4):963-970
pubmed: 28328714
Int J Sports Physiol Perform. 2014 Jan;9(1):173-80
pubmed: 23628675
J Strength Cond Res. 2018 May;32(5):1311-1315
pubmed: 29401200
Med Sci Sports Exerc. 2005 Jun;37(6):955-63
pubmed: 15947720
J Sports Med Phys Fitness. 1995 Mar;35(1):20-4
pubmed: 7474988
Am J Hum Genet. 2003 Sep;73(3):627-31
pubmed: 12879365
Ann Hum Genet. 2018 Sep;82(5):254-264
pubmed: 29603120
Int J Sports Med. 2000 Apr;21(3):185-90
pubmed: 10834350
J Sports Sci. 2001 Jul;19(7):499-505
pubmed: 11461053
J Sci Med Sport. 2015 Jan;18(1):114-8
pubmed: 24485392
J Appl Physiol (1985). 2000 Jan;88(1):61-5
pubmed: 10642363
Br J Sports Med. 1999 Feb;33(1):14-8
pubmed: 10027051
J Sports Med Phys Fitness. 2009 Mar;49(1):19-24
pubmed: 19188891
J Strength Cond Res. 2010 May;24(5):1356-60
pubmed: 20386481
Med Sci Sports Exerc. 2009 Jan;41(1):35-73
pubmed: 19123262
J Biol Chem. 2015 Jan 23;290(4):2303-11
pubmed: 25371203
Eur J Sport Sci. 2017 Oct;17(9):1177-1183
pubmed: 28753391
J Strength Cond Res. 2016 Apr;30(4):1171-6
pubmed: 26340466
Med Sci Sports Exerc. 1998 Jul;30(7):1118-22
pubmed: 9662682
J Strength Cond Res. 2013 Feb;27(2):310-4
pubmed: 22505133
Twin Res Hum Genet. 2007 Dec;10(6):812-20
pubmed: 18179392
Eur J Sport Sci. 2016 Sep;16(6):694-701
pubmed: 26324221
PLoS One. 2016 Jun 02;11(6):e0156316
pubmed: 27253421
J Sports Med Phys Fitness. 1996 Dec;36(4):255-60
pubmed: 9062048
J Sci Med Sport. 2010 Sep;13(5):526-30
pubmed: 19850519
Med Sci Sports Exerc. 2013 May;45(5):892-900
pubmed: 23190598
Muscle Nerve. 2000 Jan;23(1):90-7
pubmed: 10590411
Eur J Appl Physiol. 2007 Oct;101(3):293-300
pubmed: 17602238