Landscape of Multidrug-Resistant Gram-Negative Infections in Egypt: Survey and Literature Review.
Egypt
Gram-negative bacteria
hospital-acquired pneumonia
intra-abdominal infections
multidrug resistance
urinary tract infections
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
01
2021
accepted:
26
03
2021
entrez:
3
6
2021
pubmed:
4
6
2021
medline:
4
6
2021
Statut:
epublish
Résumé
This article is the first to review published reports on the prevalence of multidrug-resistant (MDR) gram-negative infections in Egypt and gain insights into antimicrobial resistance (AMR) surveillance and susceptibility testing capabilities of Egyptian medical centers. A literature review and online survey were conducted. The online survey and literature review reported high prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (19-85.24% of This survey has highlighted the presence of knowledge gaps as well as limitations in the surveillance and monitoring capabilities of AMR in Egypt, with most laboratories lacking rapid diagnostics and molecular testing. Future efforts in Egypt should focus on tackling these issues via nationwide initiatives, including understanding the AMR trends in the country, capacity building of laboratories and their staff to correctly and timely identify AMR, and introducing newer antimicrobials for targeting emerging resistance mechanisms in Gram-negative species.
Identifiants
pubmed: 34079301
doi: 10.2147/IDR.S298920
pii: 298920
pmc: PMC8163635
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1905-1920Informations de copyright
© 2021 El-Kholy et al.
Déclaration de conflit d'intérêts
Professor Noha Elsharnouby reports non-financial support from Pfizer, during the conduct of the study. Dr Mohamed Abdel Aziz, Ahmed Mohamed Helmy, and Ramy Kotb report being employees of Pfizer during the conduct of the study and outside the submitted work. The authors report no other potential conflicts of interest for this work.
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