Galectins in the Pathogenesis of Common Retinal Disease.
VEGF
age-related macula degeneration
angiogenesis
diabetic retinopathy
leakage
retina
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
03
2021
accepted:
29
04
2021
entrez:
3
6
2021
pubmed:
4
6
2021
medline:
4
6
2021
Statut:
epublish
Résumé
Diseases of the retina are major causes of visual impairment and blindness in developed countries and, due to an ageing population, their prevalence is continually rising. The lack of effective therapies and the limitations of those currently in use highlight the importance of continued research into the pathogenesis of these diseases. Vascular endothelial growth factor (VEGF) plays a major role in driving vascular dysfunction in retinal disease and has therefore become a key therapeutic target. Recent evidence also points to a potentially similarly important role of galectins, a family of β-galactoside-binding proteins. Indeed, they have been implicated in regulating fundamental processes, including vascular hyperpermeability, angiogenesis, neuroinflammation, and oxidative stress, all of which also play a prominent role in retinopathies. Here, we review direct evidence for pathological roles of galectins in retinal disease. In addition, we extrapolate potential roles of galectins in the retina from evidence in cancer, immune and neuro-biology. We conclude that there is value in increasing understanding of galectin function in retinal biology, in particular in the context of the retinal vasculature and microglia. With greater insight, recent clinical developments of galectin-targeting drugs could potentially also be of benefit to the clinical management of many blinding diseases.
Identifiants
pubmed: 34079467
doi: 10.3389/fphar.2021.687495
pii: 687495
pmc: PMC8165321
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
687495Informations de copyright
Copyright © 2021 Caridi, Doncheva, Sivaprasad and Turowski.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Exp Diabetes Res. 2007;2007:61038
pubmed: 18224243
Front Neurosci. 2020 Nov 11;14:570909
pubmed: 33262683
Prog Retin Eye Res. 2015 Mar;45:30-57
pubmed: 25476242
Drug Des Devel Ther. 2016 Jun 02;10:1857-67
pubmed: 27330279
J Cell Sci. 2021 Apr 1;134(7):
pubmed: 33712448
Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87
pubmed: 23978989
EXCLI J. 2020 Sep 25;19:1353-1371
pubmed: 33192217
Cell Mol Life Sci. 2020 Apr;77(7):1289-1317
pubmed: 31628495
Ophthalmologe. 2021 Jan;118(1):3-9
pubmed: 32666172
Nat Rev Dis Primers. 2021 May 6;7(1):31
pubmed: 33958600
J Exp Med. 2012 Jul 2;209(7):1363-77
pubmed: 22689825
FASEB J. 2019 Feb;33(2):2498-2513
pubmed: 30277820
Dis Mon. 2017 Mar;63(3):63-69
pubmed: 27931746
Glycobiology. 2014 Dec;24(12):1275-82
pubmed: 25108228
Curr Eye Res. 2018 Mar;43(3):368-375
pubmed: 29172741
Cell. 2011 Sep 16;146(6):873-87
pubmed: 21925313
Dev Growth Differ. 2021 Jan;63(1):59-71
pubmed: 33315237
Oncotarget. 2017 May 16;8(20):32505-32522
pubmed: 28455954
Eye Brain. 2010;2:99-116
pubmed: 23226947
Annu Rev Pathol. 2007;2:251-75
pubmed: 18039100
Int J Mol Sci. 2019 Sep 25;20(19):
pubmed: 31557880
Circ Res. 2010 Apr 30;106(8):1319-31
pubmed: 20431074
Prog Retin Eye Res. 2018 Jan;62:1-23
pubmed: 29042326
Front Physiol. 2018 Jul 26;9:1008
pubmed: 30093867
J Exp Neurosci. 2019 Apr 10;13:1179069519836794
pubmed: 31007530
J Biochem. 1996 Jan;119(1):1-8
pubmed: 8907168
Eye (Lond). 2020 Apr;34(4):616-631
pubmed: 31576027
Indian J Pediatr. 2017 Dec;84(12):930-936
pubmed: 28674824
Mol Cell Proteomics. 2010 Jun;9(6):1031-46
pubmed: 20177130
Curr Opin Cell Biol. 2020 Feb;62:37-45
pubmed: 31518914
Curr Eye Res. 2020 Mar;45(3):361-371
pubmed: 31777296
J Biol Chem. 1995 Mar 10;270(10):5198-206
pubmed: 7890630
JCI Insight. 2017 Jul 20;2(14):
pubmed: 28724805
Nat Rev Endocrinol. 2021 Apr;17(4):195-206
pubmed: 33469209
BMC Ophthalmol. 2020 Mar 17;20(1):106
pubmed: 32183784
Biochem J. 2011 Jul 15;437(2):169-83
pubmed: 21711246
Biochim Biophys Acta. 2002 Sep 19;1572(2-3):255-62
pubmed: 12223273
Front Cell Neurosci. 2018 Sep 12;12:297
pubmed: 30258354
Ophthalmology. 2012 Nov;119(11):2312-8
pubmed: 22999634
J Cereb Blood Flow Metab. 2021 Apr;41(4):857-873
pubmed: 33736511
Brain Behav Immun. 2020 Jan;83:214-225
pubmed: 31669519
Trends Immunol. 2002 Jun;23(6):313-20
pubmed: 12072371
Glycobiology. 2015 Mar;25(3):269-83
pubmed: 25303961
Vision Res. 2017 Oct;139:221-227
pubmed: 28993218
Ophthalmology. 2016 Oct;123(10S):S98-S106
pubmed: 27664291
BMJ Open. 2013 Mar 01;3(3):
pubmed: 23457327
Biochimie. 2013 Jun;95(6):1110-9
pubmed: 23507428
Brain Sci. 2018 Feb 07;8(2):
pubmed: 29414883
Eur Respir J. 2021 May 27;57(5):
pubmed: 33214209
Nat Neurosci. 2001 Sep;4(9):877-86
pubmed: 11528418
J Biol Chem. 2013 Jan 25;288(4):2571-9
pubmed: 23223580
Oxid Med Cell Longev. 2020 Feb 10;2020:7901270
pubmed: 32104539
Invest Ophthalmol Vis Sci. 2006 Jan;47(1):415-26
pubmed: 16384992
FASEB J. 2011 Jan;25(1):242-54
pubmed: 20876211
Int J Biochem Cell Biol. 2021 Jan;130:105881
pubmed: 33181315
mBio. 2017 Jul 25;8(4):
pubmed: 28743815
J Biol Chem. 2013 Aug 16;288(33):23776-87
pubmed: 23836896
PLoS One. 2014 Jul 28;9(7):e103148
pubmed: 25068294
Diabetologia. 2018 Sep;61(9):1902-1912
pubmed: 30030554
Handb Clin Neurol. 2011;102:97-116
pubmed: 21601064
Chin Med J (Engl). 2013;126(11):2109-15
pubmed: 23769567
Mol Neurobiol. 2019 Nov;56(11):7774-7788
pubmed: 31119556
Mol Biol Cell. 2004 Aug;15(8):3580-90
pubmed: 15181153
Front Cell Neurosci. 2014 Nov 03;8:362
pubmed: 25404894
Sci Rep. 2020 Jul 22;10(1):12241
pubmed: 32699244
Prog Retin Eye Res. 2014 Sep;42:44-84
pubmed: 24984227
Blood. 2007 Oct 15;110(8):2819-27
pubmed: 17591944
J Cell Mol Med. 2019 Oct;23(10):6785-6796
pubmed: 31328390
Neuropeptides. 2018 Feb;67:56-62
pubmed: 29174415
PLoS One. 2017 Jun 26;12(6):e0177472
pubmed: 28650992
Acta Ophthalmol. 2020 Feb;98(1):e1-e12
pubmed: 31318490
Immunity. 2012 Aug 24;37(2):249-63
pubmed: 22884314
J Biomed Sci. 2005;12(1):13-29
pubmed: 15864736
J Exp Med. 2010 Aug 30;207(9):1981-93
pubmed: 20713592
Prog Retin Eye Res. 2013 May;34:19-48
pubmed: 23416119
Nature. 2011 May 19;473(7347):298-307
pubmed: 21593862
Dev Cell. 2014 Sep 8;30(5):541-52
pubmed: 25175707
Drug Discov Today. 2018 Feb;23(2):375-381
pubmed: 29133191
Front Chem. 2020 Aug 07;8:593
pubmed: 32850631
PLoS One. 2016 Jan 13;11(1):e0146887
pubmed: 26760037
Diabetes. 2005 Mar;54(3):785-94
pubmed: 15734857
Asia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):56-62
pubmed: 29376233
Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5316-22
pubmed: 26258617
Mol Cell Proteomics. 2017 Aug;16(8):1528-1546
pubmed: 28576849
Int J Mol Sci. 2021 Jan 28;22(3):
pubmed: 33525498
Cell. 2014 Feb 13;156(4):744-58
pubmed: 24529377
Nature. 2001 Dec 13;414(6865):813-20
pubmed: 11742414
Development. 2020 May 1;147(9):
pubmed: 32358096
Exp Diabetes Res. 2007;2007:51837
pubmed: 17641742
Neuropathol Appl Neurobiol. 2011 Oct;37(6):654-71
pubmed: 21501208
Int J Mol Sci. 2019 Aug 14;20(16):
pubmed: 31416282
Eye Vis (Lond). 2016 Dec 22;3:34
pubmed: 28032115
Prog Retin Eye Res. 2018 May;64:131-156
pubmed: 29175509
Front Immunol. 2018 Jul 31;9:1648
pubmed: 30108583
Mol Cells. 2018 Jan 31;41(1):27-34
pubmed: 29370690
Brain Res. 2018 Dec 1;1700:126-137
pubmed: 30016630
Eye (Lond). 2017 Jan;31(1):87-96
pubmed: 27636226
Eye (Lond). 2020 Oct;34(10):1825-1834
pubmed: 31900438
Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):462-7
pubmed: 27025601
Mol Vis. 2013 May 21;19:1047-59
pubmed: 23734074
Circulation. 2018 Oct 2;138(14):1431-1445
pubmed: 29650545
Peptides. 2012 Dec;38(2):457-62
pubmed: 22985857
Clin Ophthalmol. 2020 Jul 30;14:2171-2183
pubmed: 32801628
J Proteome Res. 2006 Oct;5(10):2599-610
pubmed: 17022631
Pharmacol Ther. 2018 Nov;191:92-122
pubmed: 29909237
Int J Mol Sci. 2021 Jan 25;22(3):
pubmed: 33504013
J Neuroinflammation. 2014 Aug 27;11:144
pubmed: 25158758
Ophthalmology. 2013 Oct;120(10):2013-22
pubmed: 23706949
Mol Vis. 2012;18:1197-214
pubmed: 22665967
Dev Cell. 2016 Oct 10;39(1):13-27
pubmed: 27693506
Prog Retin Eye Res. 2018 Sep;66:49-84
pubmed: 29609042
Oncotarget. 2017 Jul 25;8(30):49484-49501
pubmed: 28533486
Prog Retin Eye Res. 2016 Mar;51:1-40
pubmed: 26113209
Nat Rev Nephrol. 2019 Jun;15(6):346-366
pubmed: 30858582
Physiol Genomics. 2011 Oct 20;43(20):1144-52
pubmed: 21791638
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
Lancet. 2006 Nov 18;368(9549):1795-809
pubmed: 17113430
J Proteome Res. 2009 Mar;8(3):1255-62
pubmed: 19125585
Genome Med. 2012 Feb 24;4(2):16
pubmed: 22364233
Biomolecules. 2015 Mar 16;5(1):194-222
pubmed: 25786107
J Ophthalmol. 2017;2017:5053035
pubmed: 28428895
J Neuroinflammation. 2017 Jan 5;14(1):4
pubmed: 28086806
Trends Mol Med. 2021 Apr;27(4):314-331
pubmed: 33309601
Annu Rev Vis Sci. 2020 Sep 15;6:149-169
pubmed: 32936734
Eye (Lond). 2020 Jun;34(Suppl 1):1-51
pubmed: 32504038
Prog Retin Eye Res. 2020 Feb 24;:100846
pubmed: 32105772
Front Mol Neurosci. 2018 May 14;11:158
pubmed: 29867350
Nat Med. 2003 Jun;9(6):669-76
pubmed: 12778165
Glycobiology. 2014 Oct;24(10):886-91
pubmed: 25138305
Nat Commun. 2012;3:1208
pubmed: 23169049
Ophthalmic Physiol Opt. 2020 Mar;40(2):140-170
pubmed: 32100327
Prog Retin Eye Res. 2015 Nov;49:67-81
pubmed: 26113211
J Immunol. 2017 Jun 15;198(12):4792-4801
pubmed: 28500071
Surv Ophthalmol. 2009 May-Jun;54(3):426; author reply 426-7
pubmed: 19422970
EMBO Mol Med. 2018 Oct;10(10):
pubmed: 30224384
Surv Ophthalmol. 2000 Sep-Oct;45(2):115-34
pubmed: 11033038
Nat Rev Drug Discov. 2009 Aug;8(8):661-77
pubmed: 19629075
Oncotarget. 2017 Nov 3;9(1):1380-1402
pubmed: 29416702
Cell Death Differ. 1999 Aug;6(8):711-21
pubmed: 10467344
Sci Rep. 2016 Nov 29;6:38038
pubmed: 27897264
Anticancer Res. 2020 Jun;40(6):3191-3201
pubmed: 32487613
Angiogenesis. 2014 Oct;17(4):839-49
pubmed: 24719187
Sci Rep. 2015 Dec 09;5:17946
pubmed: 26648523
PLoS One. 2013 Jun 17;8(6):e67029
pubmed: 23799140
Int J Mol Sci. 2018 Mar 22;19(4):
pubmed: 29565290
Angiogenesis. 2008;11(2):109-19
pubmed: 18293091
Semin Cell Dev Biol. 2018 Nov;83:42-50
pubmed: 29501720
Oxid Med Cell Longev. 2018 Sep 5;2018:3420187
pubmed: 30254714
EMBO J. 2019 Sep 16;38(18):e100811
pubmed: 31436334
Ophthalmologica. 2012;227(3):115-31
pubmed: 21952513
Neurotherapeutics. 2015 Oct;12(4):896-909
pubmed: 26306439
Am J Pathol. 2013 Apr;182(4):1379-90
pubmed: 23416159
Carcinogenesis. 2019 Apr 29;40(2):313-323
pubmed: 30624618
Front Cell Neurosci. 2019 May 14;13:157
pubmed: 31156388
Nature. 2005 Dec 15;438(7070):960-6
pubmed: 16355161
Pharmaceuticals (Basel). 2019 Apr 11;12(2):
pubmed: 30978966
Transl Vis Sci Technol. 2020 Oct 14;9(11):16
pubmed: 33117608
J Exp Clin Cancer Res. 2019 Oct 22;38(1):423
pubmed: 31640796
Int J Biochem Cell Biol. 2006;38(5-6):752-65
pubmed: 16165393
World J Diabetes. 2015 Apr 15;6(3):489-99
pubmed: 25897358
Cell Physiol Biochem. 2018;48(2):705-717
pubmed: 30025404
Proteomics Clin Appl. 2014 Apr;8(3-4):218-31
pubmed: 24550151
Physiol Rev. 2005 Jul;85(3):845-81
pubmed: 15987797
Nat Rev Drug Discov. 2016 Jun;15(6):385-403
pubmed: 26775688
J Cell Sci. 2018 May 1;131(9):
pubmed: 29717004
Cardiovasc J Afr. 2014 Sep-Oct;25(5):228-32
pubmed: 25629539
Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4781-7
pubmed: 20393105
Cell Death Differ. 2015 Mar;22(3):377-88
pubmed: 25257172
Ophthalmology. 2009 Oct;116(10 Suppl):S1-7
pubmed: 19800534
Int J Mol Sci. 2017 Dec 09;18(12):
pubmed: 29232825
Annu Rev Pathol. 2016 May 23;11:251-81
pubmed: 26907525
Clin Exp Hypertens. 2012;34(6):397-401
pubmed: 22468968
Clin Optom (Auckl). 2020 May 05;12:67-73
pubmed: 32440245
Neuromolecular Med. 2021 Jun;23(2):267-284
pubmed: 32865657
Artif Organs. 2003 Nov;27(11):963-74
pubmed: 14616515
FEBS Lett. 2013 Jun 27;587(13):2008-17
pubmed: 23684651
PLoS One. 2014 May 16;9(5):e97302
pubmed: 24837086
J Immunol. 2009 Jan 15;182(2):1167-73
pubmed: 19124760
N Engl J Med. 2015 Mar 26;372(13):1193-203
pubmed: 25692915
Front Cell Dev Biol. 2021 Jan 25;8:612812
pubmed: 33569380
J Clin Med. 2020 Nov 12;9(11):
pubmed: 33198349
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3244-52
pubmed: 20071673
J Biol Chem. 2011 Aug 26;286(34):29913-21
pubmed: 21715322
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):1-4
pubmed: 18708615
Cardiovasc Diabetol. 2015 Jun 06;14:73
pubmed: 26047815
Sci Rep. 2017 Nov 23;7(1):16168
pubmed: 29170525
Exp Diabetes Res. 2007;2007:43603
pubmed: 17641741
Nat Commun. 2016 Apr 12;7:11302
pubmed: 27066737