Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.
Enterobacter cloacae
cirA siderophore receptor
Cefiderocol
antibiotic resistance
carbapenemase
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
09 03 2022
09 03 2022
Historique:
received:
09
03
2021
pubmed:
4
6
2021
medline:
16
3
2022
entrez:
3
6
2021
Statut:
ppublish
Résumé
We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
Identifiants
pubmed: 34079986
pii: 6291426
doi: 10.1093/cid/ciab511
pmc: PMC8906715
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Carbapenems
0
Cephalosporins
0
Siderophores
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
905-908Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
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