Prevalence of positive toxicology analysis from the French national registry for sudden unexpected infant death (Tox-MIN).
French national registry
Sudden unexpected infant death
child abuse
toxicological analysis
Journal
Clinical toxicology (Philadelphia, Pa.)
ISSN: 1556-9519
Titre abrégé: Clin Toxicol (Phila)
Pays: England
ID NLM: 101241654
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
pubmed:
4
6
2021
medline:
31
3
2022
entrez:
3
6
2021
Statut:
ppublish
Résumé
Sudden unexpected infant death (SUID) remains the leading cause of postnatal mortality in many countries. French and international guidelines recommend a thorough examination with toxicology studies. The main objective was to determine the prevalence of toxic detection and positive analyses. The secondary objectives were to describe the different toxics and compare children with positive (Tox+) and negative results (Tox-) with other SUID risk factors. We used the data registered from May 2015 to December 2018 by the French national SUID registry (OMIN). It collects data for all SUID cases admitted to any of the 35 participating French SUID referral centers. Of the 624 SUID cases registered in the OMIN, a post-mortem toxicological analysis was performed in 398 infants. Thirty-six patients (9%) were positives for expected (Etox+ ( The high rate of positive results warrants routine toxicology testing. The imputability of identified molecules is complicated by the presence of other known risk factors for SUID.
Sections du résumé
BACKGROUND
BACKGROUND
Sudden unexpected infant death (SUID) remains the leading cause of postnatal mortality in many countries. French and international guidelines recommend a thorough examination with toxicology studies.
OBJECTIVES
OBJECTIVE
The main objective was to determine the prevalence of toxic detection and positive analyses. The secondary objectives were to describe the different toxics and compare children with positive (Tox+) and negative results (Tox-) with other SUID risk factors.
DESIGN AND METHODS
METHODS
We used the data registered from May 2015 to December 2018 by the French national SUID registry (OMIN). It collects data for all SUID cases admitted to any of the 35 participating French SUID referral centers.
RESULTS
RESULTS
Of the 624 SUID cases registered in the OMIN, a post-mortem toxicological analysis was performed in 398 infants. Thirty-six patients (9%) were positives for expected (Etox+ (
CONCLUSION
CONCLUSIONS
The high rate of positive results warrants routine toxicology testing. The imputability of identified molecules is complicated by the presence of other known risk factors for SUID.
Identifiants
pubmed: 34080518
doi: 10.1080/15563650.2021.1933005
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM