The Moderating Effects of Genetic Variations on Changes in Physical Activity Level and Cardiorespiratory Fitness in Response to a Life-Style Intervention: A Randomized Controlled Trial.
Journal
Psychosomatic medicine
ISSN: 1534-7796
Titre abrégé: Psychosom Med
Pays: United States
ID NLM: 0376505
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
entrez:
3
6
2021
pubmed:
4
6
2021
medline:
21
10
2021
Statut:
ppublish
Résumé
Prior studies identified single nucleotide polymorphisms (SNPs) associated with physical activity (PA) level in a natural environment and intervention study: rs978656-DNAPTP6, rs10887741-PAPSS2, rs7279064-C18orf2, and rs6265-BDNF. Using the four SNPs' polygenic score (PGS), we examined whether PGS moderates a life-style intervention's effect on changes in PA level and cardiorespiratory fitness (CRF). This is a secondary analysis of Look AHEAD, a multicenter randomized controlled trial designed to test the health benefits of a life-style intervention among 2675 participants with overweight/obesity and type 2 diabetes (ages, 45-76 years). Using linear mixed-effects models, level of PA (Paffenbarger PA questionnaire) and treadmill-assessed CRF were each regressed on four SNPs' PGS, study time (baseline, year 1, and year 4), intervention arm, and interactions between the three. Models adjusted for age, sex, body mass index, ancestry principal components (population stratification), and study sites, with Bonferroni corrections for multiple testing (α < .005). Effect modification by age was examined. PGS was not predictive of change in CRF or PA level in response to intervention. In analyses without PGS by intervention by time, the relationships between PGS and PA phenotypes were modified by age (p interaction = .048 for CRF and .058 for PA), such that a 1-unit increase in PGS was associated with 24 kcal · wk-1 more in moderate-intensity PA and 0.004 MET higher CRF only among older groups (age >55 years for CRF, >60 years for PA level). The effects of the intervention on PA and CRF were not moderated by the four SNPs. Future studies with extended SNP list should confirm the findings on effect modification by age.
Identifiants
pubmed: 34080585
doi: 10.1097/PSY.0000000000000930
pii: 00006842-202106000-00007
pmc: PMC9922170
mid: NIHMS1679626
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
440-448Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK057151
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057154
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK056992
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057171
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057182
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057002
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057177
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001066
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057078
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057008
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057149
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL140817
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001346
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057135
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046204
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR002719
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000056
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057219
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DK069002
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057136
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057131
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000051
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK056990
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057178
Pays : United States
Informations de copyright
Copyright © 2021 by the American Psychosomatic Society.
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