Non-initiation of prescribed medication from a Spanish health professionals' perspective: A qualitative exploration based on Grounded Theory.
medication adherence
primary health care
qualitative research
shared decision making
Journal
Health & social care in the community
ISSN: 1365-2524
Titre abrégé: Health Soc Care Community
Pays: England
ID NLM: 9306359
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
24
02
2021
received:
29
09
2020
accepted:
13
04
2021
pubmed:
4
6
2021
medline:
31
12
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
We explore, from the perspective of primary care health professionals, the motivations that lead patients to not initiate prescribed treatments, by developing a qualitative study in Spanish primary care. Six focus groups (N = 46) were conducted with general practitioners, nurse practitioners, social workers and community pharmacists and carried out in primary care (PC) of Barcelona Province, from April to July of 2018. The 46 participants were identified by three general practitioners and two pharmacists. In the interviews, the reasons for non-initiation of PC patients' medication were explored. Triangulated content analysis was performed. Patients' perspective, analysed in a previous study, and professionals' perspective agree on most of the factors that affect non-initiation. New factors were categorized into existent categories, confirming, and supplementing the model developed with patients. Health professionals identified some new factors which were not present in the patients' discourse, such as stigma related to the drug, hidden reasons for consultation, the role of nurses in prescription and support, the role of the pharmacy technician, illiteracy and lack of social support. The professionals confirm and expand on the Theoretical Model of Medication Non-Initiation. Primary care professionals should consider the factors described when prescribing a new medication. Knowledge contributed by the model should guide the design of interventions to improve initiation.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e213-e221Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Aznar-Lou, I., Fernández, A., Gil-Girbau, M., Fajó-Pascual, M., Moreno-Peral, P., Peñarrubia-María, M. T., Serrano-Blanco, A., Sánchez-Niubó, A., March-Pujol, M. A., Jové, A. M., & Rubio-Valera, M. (2017). Initial medication non-adherence: Prevalence and predictive factors in a cohort of 1.6 million primary care patients. British Journal of Clinical Pharmacology, 83, 1328-1340. https://doi.org/10.1111/bcp.13215
Aznar-Lou, I., Fernández, A., Gil-Girbau, M., Sabés-Figuera, R., Fajó-Pascual, M., Peñarrubia-María, M. T., Serrano-Blanco, A., Moreno-Peral, P., Sánchez-Niubó, A., March-Pujol, M., & Rubio-Valera, M. (2017). Impact of initial medication non-adherence on use of healthcare services and sick leave: A longitudinal study in a large primary care cohort in Spain. The British Journal of General Practice, 67, e614-e622. https://doi.org/10.3399/bjgp17X692129
Aznar-Lou, I., Pottegård, A., Fernández, A., Peñarrubia-María, M. T., Serrano-Blanco, A., Sabés-Figuera, R., Gil-Girbau, M., Fajó-Pascual, M., Moreno-Peral, P., & Rubio-Valera, M. (2018). Effect of copayment policies on initial medication non-adherence according to income: A population-based study. BMJ Quality & Safety, 27, 878-891. https://doi.org/10.1136/bmjqs-2017-007416
Baixauli Fernández, V. J. (2008). Pharmaceutical consultation and pharmacotherapy consult services as pharmaceutical care activities. Pharmaceutical Care España, 10, 22-31.
Brugués Brugués, A., Peris Grao, A., Martí Aguasca, L., & Flores Mateo, G. (2008). Abordaje de la demanda de visitas espontáneas de un equipo de atención primaria mediante una guía de intervenciones de enfermería [An approach to acute diseases using a nursing practice guide]. Atencion Primaria, 40, 387-391. https://doi.org/10.1157/13125403
Charmaz, K. (2006). Constructing grounded theory: A practical guide through qualitative analysis. SAGE Publishing.
Courtenay, M., Gerada, C., & Haywood, J. (2011). Working with non-medical prescribers. The British Journal of General Practice, 61, 85-86. https://doi.org/10.3399/bjgp11X556155
Cruden, N. L., Din, J. N., Janssen, C., Smith, R., Hilton, J. D., Klinke, W. P., Carere, R. G., Robinson, S. D., & Siega, A. D. (2014). Delay in filling first clopidogrel prescription after coronary stenting is associated with an increased risk of death and myocardial infarction. Journal of the American Heart Association, 3, e000669. https://doi.org/10.1161/JAHA.113.000669
Englund, L., & Svärdsudd, K. (2000). Sick-listing habits among general practitioners in a Swedish county. Scandinavian Journal of Primary Health Care, 18, 81-86. https://doi.org/10.1080/028134300750018954
Fernández Rodríguez, S., López González, M. L., Comas Fuentes, A., García Cueto, E., & Cueto Espinar, A. (2003). Categorización de factores psicosociales asociados al cumplimiento farmacológico anthipertensivo. Psicothema, 15, 82-87.
Gil-Girbau, M., Aznar-Lou, I., Peñarrubia-María, M. T., Moreno-Peral, P., Fernández, A., Bellón, J. Á., Jové, A. M., Mendive, J., Fernández-Vergel, R., Figueiras, A., March-Pujol, M., & Rubio-Valera, M. (2020). Reasons for medication non-initiation: A qualitative exploration of the patients' perspective. Research in Social & Administrative Pharmacy, 16, 663-672. https://doi.org/10.1016/j.sapharm.2019.08.002
González López-Valcárcel, B., Librero, J., García-Sempere, A., Peña, L. M., Bauer, S., Puig-Junoy, J., Oliva, J., Peiró, S., & Sanfélix-Gimeno, G. (2017). Effect of cost sharing on adherence to evidence-based medications in patients with acute coronary syndrome. Heart, 103, 1082-1088. https://doi.org/10.1136/heartjnl-2016-310610
Goulding, C. (2017). Navigating the complexities of grounded theory research in advertising. Journal of Advertising. https://doi.org/10.1080/00913367.2017.1281775
Hoffmann, T. C., Erueti, C., & Glasziou, P. P. (2013). Poor description of non-pharmacological interventions: Analysis of consecutive sample of randomised trials. BMJ, 347, f3755. https://doi.org/10.1136/bmj.f3755
Isanta Pomar, C., Rivera Torres, P., Pedraja Iglesias, M., & Giménez Blasco, N. (2000). Características de las personas que acuden a las consultas de demanda del centro de salud sin citación previa. Revista Espanola de Salud Publica, 74, 263-274.
Kardas, P., Lewek, P., & Matyjaszczyk, M. (2013). Determinants of patient adherence: A review of systematic reviews. Frontiers in Pharmacology, 4, 91. https://doi.org/10.3389/fphar.2013.00091
Kim, J., Ozzoude, M., Nakajima, S., Shah, P., Caravaggio, F., Iwata, Y., De Luca, V., Graff-Guerrero, A., & Gerretsen, P. (2020). Insight and medication adherence in schizophrenia: An analysis of the CATIE trial. Neuropharmacology, 168, 107634. https://doi.org/10.1016/j.neuropharm.2019.05.011
Lemstra, M., Nwankwo, C., Bird, Y., & Moraros, J. (2018). Primary nonadherence to chronic disease medications: A meta-analysis. Patient Preference and Adherence, 12, 721-731. https://doi.org/10.2147/PPA.S161151
Murphy, E., Dingwall, R., Greatbatch, D., Parker, S., & Watson, P. (1998). Qualitative research methods in health technology assessment: A review of the literature. Health Technology Assessment, 2, iii-274. https://doi.org/10.3310/hta2160
O'Brien, B. C., Harris, I. B., Beckman, T. J., Reed, D. A., & Cook, D. A. (2014). Standards for reporting qualitative research: A synthesis of recommendations. Academic Medicine, 89, 1245-1251. https://doi.org/10.1097/ACM.0000000000000388
Peters, M., Potter, C. M., Kelly, L., & Fitzpatrick, R. (2019). Self-efficacy and health-related quality of life: A cross-sectional study of primary care patients with multi-morbidity. Health and Quality of Life Outcomes, 17, 37. https://doi.org/10.1186/s12955-019-1103-3
Polinski, J. M., Kesselheim, A. S., Frolkis, J. P., Wescott, P., Allen-Coleman, C., & Fischer, M. A. (2014). A matter of trust: Patient barriers to primary medication adherence. Health Education Research, 29, 755-763. https://doi.org/10.1093/her/cyu023
Pottegård, A., Christensen, R. D. P., Houji, A., Christiansen, C. B., Paulsen, M. S., Thomsen, J. L., & Hallas, J. (2014). Primary non-adherence in general practice: A Danish register study. European Journal of Clinical Pharmacology, 70, 757-763. https://doi.org/10.1007/s00228-014-1677-y
Rubio-Valera, M., Fernández, A., Evans-Lacko, S., Luciano, J. V., Thornicroft, G., Aznar-Lou, I., & Serrano-Blanco, A. (2016). Impact of the mass media OBERTAMENT campaign on the levels of stigma among the population of Catalonia, Spain. European Psychiatry, 31, 44-51. https://doi.org/10.1016/j.eurpsy.2015.10.005
Rushforth, B., McCrorie, C., Glidewell, L., Midgley, E., & Foy, R. (2016). Barriers to effective management of type 2 diabetes in primary care: Qualitative systematic review. The British Journal of General Practice, 66, e114-e127. https://doi.org/10.3399/bjgp16X683509
Shah, N. R., Hirsch, A. G., Zacker, C., Taylor, S., Wood, G. C., & Stewart, W. F. (2009). Factors associated with first-fill adherence rates for diabetic medications: A cohort study. Journal of General Internal Medicine, 24, 233-237. https://doi.org/10.1007/s11606-008-0870-z
Smith, M. (2013). Anti-stigma campaigns: Time to change. The British Journal of Psychiatry. Supplement, 55, s49-s50. https://doi.org/10.1192/bjp.bp.113.126813
Sørensen, K., Pelikan, J. M., Röthlin, F., Ganahl, K., Slonska, Z., Doyle, G., Fullam, J., Kondilis, B., Agrafiotis, D., Uiters, E., Falcon, M., Mensing, M., Tchamov, K., van den Broucke, S., Brand, H., & HLS-EU Consortium. (2015). Health literacy in Europe: Comparative results of the European health literacy survey (HLS-EU). European Journal of Public Health, 25, 1053-1058. https://doi.org/10.1093/eurpub/ckv043
Srimongkon, P., Aslani, P., & Chen, T. F. (2018). Consumer-related factors influencing antidepressant adherence in unipolar depression: A qualitative study. Patient Preference and Adherence, 12, 1863-1873. https://doi.org/10.2147/PPA.S160728
Swart, K., van Vilsteren, M., van Hout, W., Draak, E., van der Zwaard, B. C., van der Horst, H. E., Hugtenburg, J. G., & Elders, P. (2018). Factors related to intentional non-initiation of bisphosphonate treatment in patients with a high fracture risk in primary care: A qualitative study. BMC Family Practice, 19, 141. https://doi.org/10.1186/s12875-018-0828-0
Tamblyn, R., Eguale, T., Huang, A., Winslade, N., & Doran, P. (2014). The incidence and determinants of primary nonadherence with prescribed medication in primary care: A cohort study. Annals of Internal Medicine, 160, 441-450. https://doi.org/10.7326/M13-1705
Torres-Robles, A., Wiecek, E., Tonin, F. S., Benrimoj, S. I., Fernandez-Llimos, F., & Garcia-Cardenas, V. (2018). Comparison of interventions to improve long-term medication adherence across different clinical conditions: A systematic review with network meta-analysis. Frontiers in Pharmacology, 9, 1454. https://doi.org/10.3389/fphar.2018.01454
Vázquez, M. L., Rejane, M., Mogollón, A. S., Fernández de Sanmamed, M. J., Delgado, M. E., & Vargas, I. (2006). Introducción a las técnicas de investigación aplicadas en salud. Universitat Autònoma de Barcelona.
Vrijens, B., De Geest, S., Hughes, D. A., Przemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., Matyjaszczyk, M., Mshelia, C., Clyne, W., Aronson, J. K., Urquhart, J., & ABC Project Team. (2012). A new taxonomy for describing and defining adherence to medications. British Journal of Clinical Pharmacology, 73, 691-705. https://doi.org/10.1111/j.1365-2125.2012.04167.x