Mirtazapine reduces susceptibility to hypocapnic central sleep apnea in males with sleep-disordered breathing: a pilot study.
CO2 reserve
central sleep apnea
mirtazapine
sleep disordered-breathing
spinal cord injury
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
pubmed:
4
6
2021
medline:
23
7
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
Studies in humans and animal models with spinal cord injury (SCI) have demonstrated that medications targeting serotonin receptors may decrease the susceptibility to central sleep-disordered breathing (SDB). We hypothesized that mirtazapine would decrease the propensity to develop hypocapnic central sleep apnea (CSA) during sleep. We performed a single-blind pilot study on a total of 10 men with SDB (7 with chronic SCI and 3 noninjured) aged 52.0 ± 11.2 yr. Participants were randomly assigned to either mirtazapine (15 mg at bedtime) or a placebo for at least 1 wk, followed by a 7-day washout period before crossing over to the other intervention. Split-night studies included polysomnography and induction of hypocapnic CSA using a noninvasive ventilation (NIV) protocol. The primary outcome was CO
Identifiants
pubmed: 34080920
doi: 10.1152/japplphysiol.00838.2020
pmc: PMC8325612
doi:
Substances chimiques
Mirtazapine
A051Q2099Q
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
414-423Subventions
Organisme : CSRD VA
ID : I01 CX001040
Pays : United States
Organisme : CSRD VA
ID : IK2 CX000547
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL053443
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130552
Pays : United States
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