Efficacy of ulipristal acetate in women with fibroid induced menorrhagia: A systematic review and meta-analysis.
Adverse effects
Amenorrhoea
Fibroids
Liver injury
Quality of life
Ulipristal acetate
Journal
Journal of gynecology obstetrics and human reproduction
ISSN: 2468-7847
Titre abrégé: J Gynecol Obstet Hum Reprod
Pays: France
ID NLM: 101701588
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
29
03
2021
revised:
27
05
2021
accepted:
28
05
2021
pubmed:
4
6
2021
medline:
16
12
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
To evaluate the efficacy of UPA in women with fibroid induced menorrhagia. Embase, MEDLINE, CAB Abstracts, Cochrane Central Register of Controlled Trials, PsychInfo were searched up to 18th May 2020 and updated on 7th February 2021. Randomised controlled trials evaluating the efficacy of UPA in women with fibroid induced menorrhagia were included in the study. Two authors independently reviewed and extracted the study data. Statistical heterogeneity was quantified using I This review demonstrates the efficacy of UPA in achieving amenorrhoea in women with fibroid induced menorrhagia. However, the favourable dose of UPA remains inconclusive when AE profile is taken into account. Evidence remains obscure regarding liver damage and further research is warranted to attain a conclusive outcome.
Identifiants
pubmed: 34082168
pii: S2468-7847(21)00111-2
doi: 10.1016/j.jogoh.2021.102173
pii:
doi:
Substances chimiques
Contraceptive Agents
0
Norpregnadienes
0
ulipristal acetate
YF7V70N02B
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102173Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Authors have no competing interests to disclose.