Impact of radiobiological models on the calculation of the therapeutic parameters of Grid therapy for breast cancer.
Breast cancer
Bystander effect
Grid therapy
Radiobiological model
Therapeutic ratio
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
24
11
2020
revised:
02
04
2021
accepted:
07
05
2021
pubmed:
4
6
2021
medline:
12
1
2022
entrez:
3
6
2021
Statut:
ppublish
Résumé
Therapeutic advantages of Grid therapy have been demonstrated in several theoretical studies using the standard linear-quadratic (LQ) model. However, the suitability of the LQ model when describing cell killing at highly modulated radiation fields has been questioned. In this study, we have applied an extended LQ model to recalculate therapeutic parameters of Grid therapy. This study shows that incorporating the bystander effects in the radiobiological models would significantly change the theoretical predictions and conclusion of Grid therapy, especially at high dose gradient fields.
Identifiants
pubmed: 34082185
pii: S0969-8043(21)00181-0
doi: 10.1016/j.apradiso.2021.109776
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109776Informations de copyright
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