Genuine Empty Follicle Syndrome: Role of Double Trigger and Delayed Oocyte Retrieval (DTDO).
DTDO
Double trigger and delayed oocyte retrieval
empty follicle syndrome
genuine empty follicle syndrome
Journal
Journal of human reproductive sciences
ISSN: 0974-1208
Titre abrégé: J Hum Reprod Sci
Pays: India
ID NLM: 101473512
Informations de publication
Date de publication:
Historique:
received:
08
12
2020
revised:
11
02
2021
accepted:
14
02
2021
entrez:
4
6
2021
pubmed:
5
6
2021
medline:
5
6
2021
Statut:
ppublish
Résumé
Empty follicle syndrome (EFS) is a condition of undetermined etiology where no oocytes are retrieved in an ART cycle despite adequate response to ovarian stimulation and diligent follicular aspiration. Because of the rarity of this condition, no much published strategies are available to tackle this. The aim of this study was to evaluate whether sequential administration of gonadotropin-releasing hormone agonist (GnRHa) and human chorionic gonadotropin (hCG) as a trigger at 40 h and 36 h, respectively, before oocyte retrieval (OCR) could correct genuine empty follicle syndrome (GEFS). This retrospective observational cohort study was conducted in a tertiary fertility center over a period of 6 years from January 2014 to December 2019. Patients with a history of GEFS were administered GnRHa and recombinant hCG subcutaneously at 40 h and 36 h, respectively, before OCR, i.e., double trigger and delayed oocyte retrieval (DTDO) ( Comparison between the groups was analysed by Fisher's exact test and paired Patients in the DTDO group showed a significant improvement ( Our findings implicate that double trigger and delayed OCR (DTDO) is a safe and efficacious treatment strategy for GEFS.
Sections du résumé
BACKGROUND
BACKGROUND
Empty follicle syndrome (EFS) is a condition of undetermined etiology where no oocytes are retrieved in an ART cycle despite adequate response to ovarian stimulation and diligent follicular aspiration. Because of the rarity of this condition, no much published strategies are available to tackle this.
AIM
OBJECTIVE
The aim of this study was to evaluate whether sequential administration of gonadotropin-releasing hormone agonist (GnRHa) and human chorionic gonadotropin (hCG) as a trigger at 40 h and 36 h, respectively, before oocyte retrieval (OCR) could correct genuine empty follicle syndrome (GEFS).
STUDY SETTING AND DESIGN
METHODS
This retrospective observational cohort study was conducted in a tertiary fertility center over a period of 6 years from January 2014 to December 2019. Patients with a history of GEFS were administered GnRHa and recombinant hCG subcutaneously at 40 h and 36 h, respectively, before OCR, i.e., double trigger and delayed oocyte retrieval (DTDO) (
STATISTICAL ANALYSIS
METHODS
Comparison between the groups was analysed by Fisher's exact test and paired
RESULTS
RESULTS
Patients in the DTDO group showed a significant improvement (
CONCLUSION
CONCLUSIONS
Our findings implicate that double trigger and delayed OCR (DTDO) is a safe and efficacious treatment strategy for GEFS.
Identifiants
pubmed: 34083990
doi: 10.4103/jhrs.jhrs_230_20
pii: JHRS-14-36
pmc: PMC8057151
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36-41Informations de copyright
Copyright: © 2021 Journal of Human Reproductive Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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