Extracellular Vesicles for the Treatment of Radiation Injuries.
acute radiation syndrome
endothelial cells
extracellular vesicles
macrophages
medical countermeasures against radiation
mesenchymal stromal/stem cells
radiation injuries
radio mitigation
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
02
2021
accepted:
04
05
2021
entrez:
4
6
2021
pubmed:
5
6
2021
medline:
5
6
2021
Statut:
epublish
Résumé
Normal tissue injury from accidental or therapeutic exposure to high-dose radiation can cause severe acute and delayed toxicities, which result in mortality and chronic morbidity. Exposure to single high-dose radiation leads to a multi-organ failure, known as acute radiation syndrome, which is caused by radiation-induced oxidative stress and DNA damage to tissue stem cells. The radiation exposure results in acute cell loss, cell cycle arrest, senescence, and early damage to bone marrow and intestine with high mortality from sepsis. There is an urgent need for developing medical countermeasures against radiation injury for normal tissue toxicity. In this review, we discuss the potential of applying secretory extracellular vesicles derived from mesenchymal stromal/stem cells, endothelial cells, and macrophages for promoting repair and regeneration of organs after radiation injury.
Identifiants
pubmed: 34084138
doi: 10.3389/fphar.2021.662437
pii: 662437
pmc: PMC8167064
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
662437Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK085532
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103155
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK085532
Pays : United States
Informations de copyright
Copyright © 2021 Nanduri, Duddempudi, Yang, Tamarat and Guha.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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