Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells.

Adiponectin / metabolism Blood Donors Cells, Cultured Forkhead Transcription Factors / metabolism Humans Ikaros Transcription Factor / metabolism Inflammation / immunology Interleukin-10 / metabolism Ligands Piperidines / pharmacology Receptors, Adiponectin / agonists Signal Transduction / drug effects T-Lymphocytes, Regulatory / immunology p38 Mitogen-Activated Protein Kinases / metabolism
adiponectin adiponectin receptor 1 interleukin-10 regulatory T cells type 2 inflammation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 07 03 2021
accepted: 29 04 2021
entrez: 4 6 2021
pubmed: 5 6 2021
medline: 27 10 2021
Statut: epublish

Résumé

Adiponectin is an important immunomodulatory mediator in inflammatory conditions. While we previously showed that adiponectin receptor 1 (AdipoR1) is expressed in murine regulatory T cells (Tregs), its expression in human Tregs remain unknown. Here, we examined the expression of AdipoR1 in human Tregs and whether its ligand, globular adiponectin (gAd) affects the Treg ability to secrete IL-10 and the role of Type 2 (T2) inflammation in such process. Human Tregs from peripheral blood were analyzed by flow cytometry for AdipoR1, Helios and IL-10 expression. CD4 We found that a subset of human Tregs expressed AdipoR1. Importantly, more Helios Collectively, our findings suggest that adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios

Sections du résumé

Background
Adiponectin is an important immunomodulatory mediator in inflammatory conditions. While we previously showed that adiponectin receptor 1 (AdipoR1) is expressed in murine regulatory T cells (Tregs), its expression in human Tregs remain unknown. Here, we examined the expression of AdipoR1 in human Tregs and whether its ligand, globular adiponectin (gAd) affects the Treg ability to secrete IL-10 and the role of Type 2 (T2) inflammation in such process.
Methods
Human Tregs from peripheral blood were analyzed by flow cytometry for AdipoR1, Helios and IL-10 expression. CD4
Results
We found that a subset of human Tregs expressed AdipoR1. Importantly, more Helios
Conclusions
Collectively, our findings suggest that adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios

Identifiants

DOI: 10.3389/fimmu.2021.677550 PMID: 34084174 PMC: PMC8167046
pubmed: 34084174
doi: 10.3389/fimmu.2021.677550
pmc: PMC8167046
doi:

Substances chimiques

ADIPOQ protein, human 0
ADIPOR1 protein, human 0
AdipoRon 0
Adiponectin 0
FOXP3 protein, human 0
Forkhead Transcription Factors 0
IKZF2 protein, human 0
IL10 protein, human 0
Ligands 0
Piperidines 0
Receptors, Adiponectin 0
Interleukin-10 130068-27-8
Ikaros Transcription Factor 148971-36-2
p38 Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

677550

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL111541
Pays : United States

Informations de copyright

Copyright © 2021 Ramos-Ramírez, Malmhäll, Tliba, Rådinger and Bossios.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Nature. 2013 Nov 28;503(7477):493-9
pubmed: 24172895
Nature. 2003 Jun 12;423(6941):762-9
pubmed: 12802337
Nat Immunol. 2009 Jun;10(6):595-602
pubmed: 19412181
Biochimie. 2012 Oct;94(10):2082-8
pubmed: 22750129
J Asthma. 2013 Oct;50(8):828-35
pubmed: 23777560
J Immunol. 2010 Apr 1;184(7):3433-41
pubmed: 20181882
J Allergy Clin Immunol. 2006 Aug;118(2):389-95
pubmed: 16890763
Mol Immunol. 2010 Apr;47(7-8):1595-600
pubmed: 20226531
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
J Immunol. 2013 Mar 1;190(5):2001-8
pubmed: 23359504
J Immunol. 2013 Nov 1;191(9):4619-27
pubmed: 24068664
FEMS Immunol Med Microbiol. 2009 Aug;56(3):241-7
pubmed: 19552715
Nat Med. 2009 Aug;15(8):930-9
pubmed: 19633656
Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82
pubmed: 26037251
Proteomics. 2004 Dec;4(12):3933-42
pubmed: 15378692
PLoS One. 2008 Oct 01;3(10):e3302
pubmed: 18827879
Nature. 2009 Mar 19;458(7236):351-6
pubmed: 19182775
FEBS Lett. 2005 Dec 19;579(30):6821-6
pubmed: 16325814
Immunity. 2009 May;30(5):626-35
pubmed: 19464985
Clin Chim Acta. 2007 May 1;380(1-2):24-30
pubmed: 17343838
Science. 2009 Nov 13;326(5955):986-91
pubmed: 19797626
PLoS One. 2012;7(3):e34547
pubmed: 22479644
J Allergy Clin Immunol. 2008 Feb;121(2):326-30
pubmed: 18061654
Diabetes. 2007 Mar;56(3):583-93
pubmed: 17327425
J Biol Chem. 2012 Oct 26;287(44):36896-904
pubmed: 22948153
PLoS One. 2011;6(8):e24226
pubmed: 21918685
Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):15-23
pubmed: 24417942
Expert Opin Ther Targets. 2015;19(8):1105-25
pubmed: 25952656
Blood. 2012 Mar 22;119(12):2810-8
pubmed: 22294730
J Biol Chem. 2011 Apr 15;286(15):13460-9
pubmed: 21357416
Endocr Rev. 2005 May;26(3):439-51
pubmed: 15897298
Kidney Int. 2013 Mar;83(3):487-94
pubmed: 23283133
J Biol Chem. 2004 Jul 16;279(29):30817-22
pubmed: 15123605
Immunol Rev. 2014 May;259(1):88-102
pubmed: 24712461
Pharmacol Res. 2007 Dec;56(6):459-67
pubmed: 18029194
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10308-13
pubmed: 15210937
Scand J Immunol. 2016 Apr;83(4):244-54
pubmed: 26900653
Immunity. 2019 May 21;50(5):1232-1248.e14
pubmed: 31027998
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
Int Immunopharmacol. 2011 May;11(5):604-9
pubmed: 21094289
Iran J Basic Med Sci. 2017 Feb;20(2):107-109
pubmed: 28293385
Circulation. 2004 May 4;109(17):2046-9
pubmed: 15096450
J Immunol. 2012 Feb 1;188(3):976-80
pubmed: 22198953
Nutr Res. 2011 May;31(5):378-86
pubmed: 21636016
Nature. 2012 Jun 28;486(7404):549-53
pubmed: 22722857
Eur J Immunol. 2013 Aug;43(8):2089-100
pubmed: 23640763
J Leukoc Biol. 2006 Apr;79(4):803-8
pubmed: 16434692
Hepatology. 2008 Aug;48(2):374-84
pubmed: 18666256
Int J Mol Sci. 2020 Nov 26;21(23):
pubmed: 33256137
Biochem Biophys Res Commun. 2004 Oct 15;323(2):630-5
pubmed: 15369797
Int J Mol Sci. 2020 Feb 12;21(4):
pubmed: 32059381
PLoS One. 2011 Apr 28;6(4):e19143
pubmed: 21552570
Nat Rev Immunol. 2005 Apr;5(4):271-83
pubmed: 15775993
Endocrinology. 2005 Feb;146(2):790-6
pubmed: 15528304
Allergy. 2011 Mar;66(3):386-95
pubmed: 21039603
J Biol Chem. 2007 Jul 27;282(30):21695-703
pubmed: 17537727
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2005-10
pubmed: 11172066
Cardiovasc Diabetol. 2011 Feb 01;10:14
pubmed: 21284833
Cancer Res. 2014 Oct 15;74(20):5711-22
pubmed: 25261236
J Leukoc Biol. 2008 May;83(5):1258-66
pubmed: 18263767
Eur J Immunol. 2011 Aug;41(8):2323-32
pubmed: 21538348
Eur J Immunol. 2019 Mar;49(3):398-412
pubmed: 30620397
J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):518-533
pubmed: 31965757
Hepatology. 2010 Apr;51(4):1420-9
pubmed: 20052772
Clin Exp Immunol. 2015 Oct;182(1):90-100
pubmed: 26076982
Immunity. 2017 Sep 19;47(3):538-551.e5
pubmed: 28930662

Auteurs

Patricia Ramos-Ramírez (P)

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Carina Malmhäll (C)

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Omar Tliba (O)

Department of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY, United States.

Madeleine Rådinger (M)

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Apostolos Bossios (A)

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Adiponectine › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Personnes › Donneurs de tissus › Donneurs de sang › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Cellules › Cellules cultivées › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Facteur de transcription Ikaros › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux adipokines › Récepteurs à l'adiponectine › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Adiponectin/AdipoR1 Axis Promotes IL-10...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › p38 Mitogen-Activated Protein Kinases › Adiponectin/AdipoR1 Axis Promotes IL-10...