Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells.


Journal

Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 26 01 2021
accepted: 28 05 2021
pubmed: 5 6 2021
medline: 17 3 2022
entrez: 4 6 2021
Statut: ppublish

Résumé

Proline oxidase (POX) is mitochondrial proline-degrading enzyme of dual apoptosis/survival function. POX expression and proline availability are considered an underlying mechanism for differential POX functions. The mechanism for POX-dependent regulation of cell death/survival was studied in wild-type (MCF-7

Identifiants

pubmed: 34085157
doi: 10.1007/s00726-021-03013-8
pii: 10.1007/s00726-021-03013-8
pmc: PMC8651586
doi:

Substances chimiques

RNA, Small Interfering 0
Reactive Oxygen Species 0
TP53 protein, human 0
Tumor Suppressor Protein p53 0
Proline 9DLQ4CIU6V
Proline Oxidase EC 1.5.3.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1943-1956

Subventions

Organisme : Narodowe Centrum Nauki
ID : 2017/25/B/NZ7/02183
Organisme : Narodowe Centrum Nauki
ID : 2017/27/N/NZ7/01770
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 754432

Informations de copyright

© 2021. The Author(s).

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Auteurs

Ilona Oscilowska (I)

Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.

Thi Y L Huynh (TYL)

Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.

Weronika Baszanowska (W)

Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.

Izabela Prokop (I)

Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.

Arkadiusz Surazynski (A)

Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.

Mauro Galli (M)

Department of Medical Biology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.

Piotr Zabielski (P)

Department of Medical Biology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.

Jerzy Palka (J)

Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland. pal@umb.edu.pl.

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Classifications MeSH