Identification of the predominant human NK cell effector subset mediating ADCC against HIV-infected targets coated with BNAbs or plasma from PLWH.
ADCC
BNAbs
CD57
NK cells
PLWH
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
12
04
2021
received:
21
01
2021
accepted:
02
06
2021
pubmed:
5
6
2021
medline:
8
10
2021
entrez:
4
6
2021
Statut:
ppublish
Résumé
The potential of immunotherapy strategies utilizing broadly neutralizing antibodies (BNAbs), such as 3BNC117 and 10-1074, to limit viral replication while also facilitating clearance of HIV infected cells has heightened interest in identifying the predominant NK effector subset(s) capable of mediating antibody dependent cellular cytotoxicity (ADCC). Utilizing advanced polychromatic flow cytometry, we identified that CD57 positive NK cells from ART-suppressed in People Living With HIV (PLWH) expressed significantly higher levels of the CD16 FcγR receptor, 2B4 ADCC coreceptor, and HLA-DR activation marker while NKG2C positive NK cells expressed significantly higher levels of the CD2 ADCC coreceptor (p < 0.001, n = 32). Functionally, CD57 positive NK cells from ART-suppressed PLWH with either high or low NKG2C expansion exhibited significantly enhanced degranulation and IFN-γ production against heterologous gp120-coated ADCC targets coated with HIV reference plasma compared to CD57 negative NK cells (p = 0.0029, n = 11). CD57 positive NK cells from control donors lacking NKG2C expansion also exhibited significantly more degranulation and IFN-γ production at every timepoint tested against both heterologous ADCC targets (p = 0.019, n = 9) and HIV-1 infected autologous CD4
Identifiants
pubmed: 34086344
doi: 10.1002/eji.202149188
pmc: PMC8338900
mid: NIHMS1711165
doi:
Substances chimiques
Broadly Neutralizing Antibodies
0
HIV Antibodies
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2051-2061Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI126620
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136756
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA040554
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA049666
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120828
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA048728
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI120828
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Hum Immunol. 2000 Jan;61(1):51-64
pubmed: 10658978
J Biol Chem. 2002 Apr 5;277(14):12246-52
pubmed: 11788581
Immunol Rev. 1997 Feb;155:135-44
pubmed: 9059889
Hum Immunol. 2000 Jan;61(1):1-6
pubmed: 10658972
Antibodies (Basel). 2020 Oct 16;9(4):
pubmed: 33081115
Semin Immunol. 2017 Jun;31:11-19
pubmed: 28863960
Annu Rev Immunol. 2001;19:197-223
pubmed: 11244035
Eur J Immunol. 2003 Sep;33(9):2410-8
pubmed: 12938217
J Cell Biol. 1988 Jan;106(1):213-23
pubmed: 2448311
Clin Transl Immunology. 2017 Jul 07;6(7):e150
pubmed: 28791125
Front Immunol. 2017 Sep 20;8:1176
pubmed: 28979268
Trends Mol Med. 2011 Nov;17(11):677-85
pubmed: 21852192
J Leukoc Biol. 2002 Feb;71(2):173-83
pubmed: 11818437
AIDS. 2015 Sep 10;29(14):1767-73
pubmed: 26372382
Annu Rev Cell Dev Biol. 1996;12:181-220
pubmed: 8970726
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7505-10
pubmed: 21502492
Cell. 2014 Sep 11;158(6):1243-1253
pubmed: 25215485
Immunology. 1993 Jul;79(3):509-11
pubmed: 8104886
AIDS. 2003 Mar 7;17(4):487-94
pubmed: 12598768
Immunol Rev. 2006 Dec;214:143-54
pubmed: 17100882
J Immunol. 2002 Jun 1;168(11):5764-70
pubmed: 12023377
Mol Cell Proteomics. 2013 May;12(5):1099-114
pubmed: 23315794
Eur J Immunol. 2000 Mar;30(3):787-93
pubmed: 10741393
Transpl Immunol. 2002 Aug;10(2-3):147-64
pubmed: 12216946
PLoS Pathog. 2018 May 31;14(5):e1007104
pubmed: 29851983
Adv Immunol. 2017;133:171-207
pubmed: 28215279
J Leukoc Biol. 2009 May;85(5):871-6
pubmed: 19237639
Transplant Direct. 2017 Nov 20;3(12):e335
pubmed: 29536036
Tissue Antigens. 2004 Mar;63(3):195-203
pubmed: 14989708
Eur J Immunol. 2020 May;50(5):656-665
pubmed: 32027754
Annu Rev Immunol. 1999;17:189-220
pubmed: 10358757
Int Immunol. 2012 Dec;24(12):793-802
pubmed: 22962434
Nature. 2015 Jun 25;522(7557):487-91
pubmed: 25855300
J Immunol. 2014 May 15;192(10):4492-6
pubmed: 24740502
Blood. 2006 Jan 1;107(1):159-66
pubmed: 16150947
J Biomed Biotechnol. 2011;2011:724607
pubmed: 21765638
Viruses. 2019 Mar 09;11(3):
pubmed: 30857329
Integr Biol (Camb). 2020 May 21;12(5):109-121
pubmed: 32409824
J Virol. 2009 Jan;83(2):662-72
pubmed: 18987151
Nat Commun. 2016 Mar 03;7:10844
pubmed: 26936020
Front Immunol. 2018 Mar 16;9:474
pubmed: 29616021
Front Immunol. 2018 May 15;9:1050
pubmed: 29868012
AIDS. 2017 Mar 13;31(5):613-622
pubmed: 28225449
PLoS Pathog. 2008 Jul 11;4(7):e1000101
pubmed: 18617991
Adv Virol. 2012;2012:637208
pubmed: 22611395
Immunity. 2007 May;26(5):549-51
pubmed: 17521583
Sci Transl Med. 2015 Jul 22;7(297):297ra115
pubmed: 26203083
Blood. 2009 Oct 29;114(18):3822-30
pubmed: 19710502
Immunol Rev. 2001 Jun;181:203-14
pubmed: 11513142
Curr Pharm Des. 2009;15(28):3301-10
pubmed: 19860679
Semin Immunol. 2000 Apr;12(2):139-47
pubmed: 10764622
Trends Immunol. 2001 Nov;22(11):633-40
pubmed: 11698225
Clin Exp Immunol. 2013 Jan;171(1):107-16
pubmed: 23199330
J Immunol. 2015 Mar 15;194(6):2715-24
pubmed: 25667418
Curr Mol Med. 2006 Sep;6(6):621-9
pubmed: 17022732
Eur J Immunol. 2016 Oct;46(10):2420-2425
pubmed: 27469079
Nature. 2003 Mar 20;422(6929):307-12
pubmed: 12646921
Nature. 2001 Feb 22;409(6823):1055-60
pubmed: 11234016
Blood. 2010 Nov 11;116(19):3865-74
pubmed: 20733159
J Immunol. 2007 Aug 15;179(4):2097-104
pubmed: 17675468
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15011-6
pubmed: 14645713
J Acquir Immune Defic Syndr (1988). 1992;5(3):303-7
pubmed: 1740756
Eur J Immunol. 2001 Apr;31(4):1076-86
pubmed: 11298332
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
pubmed: 21825173
Nature. 2018 Sep;561(7724):479-484
pubmed: 30258136
Front Immunol. 2013 Dec 09;4:422
pubmed: 24367364
Eur J Immunol. 2013 May;43(5):1133-41
pubmed: 23552990
Nat Med. 2017 Feb;23(2):185-191
pubmed: 28092665
Annu Rev Immunol. 1998;16:359-93
pubmed: 9597134
Cytokine. 2013 Apr;62(1):58-63
pubmed: 23490421