Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Cell Line, Tumor
Drug Design
Humans
Molecular Dynamics Simulation
Molecular Structure
Paclitaxel
/ pharmacology
Protein Binding
Protein Kinase Inhibitors
/ chemical synthesis
Protein Serine-Threonine Kinases
/ metabolism
Pyridines
/ chemical synthesis
Pyridones
/ chemical synthesis
Pyrimidines
/ chemical synthesis
Rats, Sprague-Dawley
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
pubmed:
5
6
2021
medline:
24
8
2021
entrez:
4
6
2021
Statut:
ppublish
Résumé
Salt-inducible kinases (SIKs) are key metabolic regulators. The imbalance in SIK function is associated with the development of diverse cancers, including breast, gastric, and ovarian cancers. Chemical tools to clarify the roles of SIK in different diseases are, however, sparse and are generally characterized by poor kinome-wide selectivity. Here, we have adapted the pyrido[2,3-
Identifiants
pubmed: 34086472
doi: 10.1021/acs.jmedchem.0c02144
doi:
Substances chimiques
Antineoplastic Agents
0
G-5555 compound
0
Protein Kinase Inhibitors
0
Pyridines
0
Pyridones
0
Pyrimidines
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM