A Problem of Classification: 2 Cases of Epstein-Barr Virus + Primary Cutaneous Plasmacytoma Arising in Immunocompetent Elderly Patients.
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
pubmed:
5
6
2021
medline:
1
3
2022
entrez:
4
6
2021
Statut:
ppublish
Résumé
Primary extramedullary plasmacytoma is rare monoclonal proliferation of plasma cells, which arise in various nonosseous anatomic locations without detectable underlying systemic disease. Historically, cutaneous infiltrates rich in mature neoplastic plasma cells have fallen into one of the following categories, plasmacytoma, lymphoplasmacytic lymphoma, and marginal zone lymphoma, which included immunocytoma. Since 2005, each of these was subsumed under the marginal zone lymphoma umbrella, largely on the basis of acknowledged diagnostic difficulties in some of these cases. We describe 2 cases in which the cutaneous infiltrates consisted of a pure population of light chain-restricted mature plasma cells in the absence of any other evidence for a marginal zone proliferation, or evidence of extracutaneous involvement, including a paraprotein. We propose that primary cutaneous plasmacytoma is the accurate diagnosis and is consistent with wider nomenclature. The unusual observation of widespread Epstein-Barr virus expression in both tumors is also discussed.
Identifiants
pubmed: 34086640
doi: 10.1097/DAD.0000000000001932
pii: 00000372-202112000-00060
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e237-e240Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Tessari G, Fabbian F, Colato C, et al. Primary cutaneous plasmacytoma after rejection of a transplanted kidney: case report and review of the literature. Int J Hematol. 2004;80:361–364.
Patterson JW, Parsons JM, White RM, et al. Cutaneous involvement of multiple myeloma and extramedullary plasmacytoma. J Am Acad Dermatol. 1988;19:879.
Muscardin LM, Pulsoni A, Cerroni L. Primary cutaneous plasmacytoma: report of a case with review of the literature. J Am Acad Dermatol. 2000;43:962–965.
Kazakov DV, Belousova IE, Müller B, et al. Primary cutaneous plasmacytoma: a clinicopathological study of two cases with a long-term follow-up and review of the literature. J Cutan Pathol. 2002;29:244–248.
Wuu A, Bangert SD, Weber DM, et al. Primary cutaneous plasmacytoma. Cutis. 2014;93:E19–E21.
Rongioletti F, Patterson JW, Rebora A. The histological and pathogenetic spectrum of cutaneous disease in monoclonal gammopathies. J Cutan Pathol. 2008;35:705–721.
Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768–3785.
Requena L, Kutzner H, Palmedo G, et al. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol. 2003;139:475–486.
Loghavi S, Khoury JD, Medeiros LJ. Epstein-Barr virus-positive plasmacytoma in immunocompetent patients. Histopathology. 2015;67:225–234.
Rijlaarsdam JU, Van der Putte SC, Berti E, et al. Cutaneous immunocytomas: a clinicopathologic study of 26 cases. Histopathology. 1993;23:117–125.
Kroft SH, McKenna RW. Neoplastic hematopathology. In: Knowles D, ed. Chapter 39 Bone Marrow Manifestations of Hodgkin's and Non-hodgkin’s Lymphomas and Lymphoma-like Disorders. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2017:1462–1463.
Swerdlow SH, Campo E, Harris NL, et al. Who Classification of Tumours of Haematopoietic and Lymphoid Tissues. Mature B-Cell Neoplasms. Lyon, France: IARC; 2017:259–263.
Marks E, Shi Y, Wang Y. CD117 (kit) is a useful marker in the diagnosis of plasmablastic plasma cell myeloma. Histopathology. 2017;71:81–88.
Molina-Ruiz AM, Pulpillo A, Lasanta B, et al. A rare case of primary cutaneous plasmacytoma-like lymphoproliferative disorder following renal transplantation. J Cutan Pathol. 2012;39:685–689.
Kempf W, Mitteldorf C. Pathologic diagnosis of cutaneous lymphomas. Dermatol Clin. 2015;33:655–681.
Buffet M, Dupin N, Carlotti A, et al. Epstein-Barr virus–associated cutaneous plasmacytoma post–solid organ transplantation. Ann Dermatol Venereol. 2004;131:1085–1091.
Carbonnelle A, Mahe E, Morelon E, et al. EBV associated cutaneous plasmacytoma in a renal transplant patient. Ann Dermatol Venereol. 2004;131:1081.
Willoughby V, Werlang-Perurena A, Kelly A, et al. Primary cutaneous plasmacytoma (posttransplant lymphoproliferative disorder, plasmacytoma-like) in a heart transplant patient. Am J Dermatopathol. 2006;28:442–445.
Donner LR. Epstein-Barr virus-induced transformation of cutaneous plasmacytoma into CD30+ diffuse large B-cell lymphoma. Am J Dermatopathol. 2004;26:63–66.
Aguilera NS, Kapadia SB, Nalesnik MA, et al. Extramedullary plasmacytoma of the head and neck. Use of paraffin sections to assess clonality with in situ hybridization, growth fraction, and the presence of Epstein-Barr virus. Med Pathol. 1995;8:503–508.