Tackling COVID-19 with neutralizing monoclonal antibodies.
COVID-19
SARS-CoV-2
monoclonal antibody
neutralization
therapeutics
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
10 06 2021
10 06 2021
Historique:
received:
09
03
2021
revised:
25
04
2021
accepted:
04
05
2021
pubmed:
5
6
2021
medline:
30
6
2021
entrez:
4
6
2021
Statut:
ppublish
Résumé
Monoclonal antibodies (mAbs) have revolutionized the treatment of several human diseases, including cancer and autoimmunity and inflammatory conditions, and represent a new frontier for the treatment of infectious diseases. In the last 20 years, innovative methods have allowed the rapid isolation of mAbs from convalescent subjects, humanized mice, or libraries assembled in vitro and have proven that mAbs can be effective countermeasures against emerging pathogens. During the past year, an unprecedentedly large number of mAbs have been developed to fight coronavirus disease 2019 (COVID-19). Lessons learned from this pandemic will pave the way for the development of more mAb-based therapeutics for other infectious diseases. Here, we provide an overview of SARS-CoV-2-neutralizing mAbs, including their origin, specificity, structure, antiviral and immunological mechanisms of action, and resistance to circulating variants, as well as a snapshot of the clinical trials of approved or late-stage mAb therapeutics.
Identifiants
pubmed: 34087172
pii: S0092-8674(21)00602-4
doi: 10.1016/j.cell.2021.05.005
pmc: PMC8152891
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3086-3108Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests D.C., L.A.P., and G.S. are employees of Vir Biotechnology and may hold shares in Vir Biotechnology. L.A.P. is a former employee and may hold shares in Regeneron Pharmaceuticals. D.V. is a consultant for Vir Biotechnology. The Veesler laboratory has received a sponsored research agreement from Vir Biotechnology, Inc.
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