Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study.

Disease Progression Humans Knee Joint Longitudinal Studies Middle Aged Osteoarthritis, Knee Pain Risk Factors
Disease progression Epidemiology Knee osteoarthritis Non-steroidal anti-inflammatory drugs Risk factors

Journal

Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438

Informations de publication

Date de publication:
04 06 2021
Historique:
received: 28 08 2020
accepted: 21 05 2021
entrez: 5 6 2021
pubmed: 6 6 2021
medline: 30 6 2021
Statut: epublish

Résumé

The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis. A longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden's nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available). Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7). Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression. ClinicalTrials.gov , NCT00513422 . This original study trial was registered a priori, on August 8, 2007. The current study hypothesis arose before inspection of the data.

Sections du résumé

BACKGROUND
The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.
METHODS
A longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden's nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available).
RESULTS
Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7).
CONCLUSIONS
Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression.
TRIAL REGISTRATION
ClinicalTrials.gov , NCT00513422 . This original study trial was registered a priori, on August 8, 2007. The current study hypothesis arose before inspection of the data.

Identifiants

DOI: 10.1186/s13075-021-02540-9 PMID: 34088340 PMC: PMC8176608
pubmed: 34088340
doi: 10.1186/s13075-021-02540-9
pii: 10.1186/s13075-021-02540-9
pmc: PMC8176608
doi:

Banques de données

ClinicalTrials.gov
['NCT00513422']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

160

Références

J Rheumatol. 1988 Dec;15(12):1833-40
pubmed: 3068365
Arthritis Rheumatol. 2015 Mar;67(3):724-32
pubmed: 25369996
Ann Rheum Dis. 2005 Dec;64(12):1727-30
pubmed: 15843444
Arthritis Rheumatol. 2017 Jun;69(6):1194-1203
pubmed: 28257604
BMJ. 2013 Jun 11;346:f3195
pubmed: 23757736
Ann Rheum Dis. 2015 Mar;74(3):547-56
pubmed: 24336337
Pharmacoepidemiol Drug Saf. 2007 Mar;16(3):250-8
pubmed: 17245804
Rheum Dis Clin North Am. 2008 Aug;34(3):731-54
pubmed: 18687280
Int J Sports Phys Ther. 2014 May;9(3):320-8
pubmed: 24944850
Arthritis Rheum. 2003 Apr 15;49(2):156-63
pubmed: 12687505
Qual Life Res. 2007 May;16(4):661-73
pubmed: 17268926
Osteoarthritis Cartilage. 2014 Oct;22(10):1743-7
pubmed: 25278083
Osteoarthritis Cartilage. 2014 Mar;22(3):363-88
pubmed: 24462672
BMJ. 2004 Dec 4;329(7478):1317
pubmed: 15561731
Maturitas. 2015 Jul;81(3):394-7
pubmed: 26027908
Arthritis Care Res (Hoboken). 2010 Nov;62(11):1527-32
pubmed: 20617531
Arthritis. 2012;2012:560634
pubmed: 23346399
Arthritis Rheum. 2002 Nov;46(11):2884-92
pubmed: 12428228
Arthritis Care Res (Hoboken). 2012 Jun;64(6):847-52
pubmed: 22238208
J Bone Joint Surg Am. 1987 Jun;69(5):745-9
pubmed: 3597474
J Rheumatol. 1999 Dec;26(12):2664-74
pubmed: 10606380
Clin Ther. 2001 Jul;23(7):1080-98
pubmed: 11519772
Arthritis Rheum. 2012 Jul;64(7):2243-51
pubmed: 22422507
Ann Rheum Dis. 2020 Jun;79(6):819-828
pubmed: 32398285
Curr Opin Rheumatol. 2008 Sep;20(5):547-52
pubmed: 18698176
Ann Rheum Dis. 2015 May;74(5):851-8
pubmed: 24395557
Am J Sports Med. 2017 May;45(6):1447-1457
pubmed: 27519678
Arthritis Rheum. 2005 May;52(5):1411-7
pubmed: 15880526
Arthritis Rheum. 2000 May;43(5):995-1000
pubmed: 10817551
Arthritis Care Res (Hoboken). 2011 Aug;63(8):1115-25
pubmed: 21560257
Med Sci Sports Exerc. 2011 Jul;43(7):1334-59
pubmed: 21694556
Ann Rheum Dis. 1957 Dec;16(4):485-93
pubmed: 13498603
Ann Rheum Dis. 1992 Aug;51(8):932-7
pubmed: 1417116
Arthritis Care Res (Hoboken). 2012 Apr;64(4):465-74
pubmed: 22563589
J Rheumatol. 1995 Oct;22(10):1941-6
pubmed: 8991995
Osteoarthritis Cartilage. 2015 Jun;23(6):874-81
pubmed: 25639569
Clin Orthop Relat Res. 2015 Sep;473(9):2969-89
pubmed: 25995176
Am J Med. 2009 Sep;122(9):836-42
pubmed: 19699379
Osteoarthritis Cartilage. 2009 Jul;17(7):856-63
pubmed: 19230857
Ann Rheum Dis. 2008 Nov;67(11):1562-6
pubmed: 18258709
Arthritis Rheum. 2006 Apr 15;55(2):306-13
pubmed: 16583430
Osteoarthritis Cartilage. 2015 Apr;23(4):507-15
pubmed: 25447976
Arthritis Rheum. 2008 Oct;58(10):3183-91
pubmed: 18821708
Arthritis Rheum. 2005 Oct;52(10):3137-42
pubmed: 16200593
Curr Med Res Opin. 2013 Jun;29(6):719-29
pubmed: 23557069

Auteurs

Milena Simic (M)

Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia. milena.simic@sydney.edu.au.

Alison R Harmer (AR)

Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.

Maria Agaliotis (M)

Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.
Australia Institute of Health Service Management, University of Tasmania, Sydney, Australia.

Lillias Nairn (L)

Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.

Lisa Bridgett (L)

Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.

Lyn March (L)

Institute of Bone and Joint Research, The University of Sydney, Royal North Shore Hospital, Sydney, Australia.

Milana Votrubec (M)

Graduate School of Medicine, Notre Dame University, Sydney, Australia.

John Edmonds (J)

St George Hospital Clinical School, University of New South Wales, Sydney, Australia.

Mark Woodward (M)

The George Institute for Global Health, University of New South Wales, Sydney, Australia.
The George Institute for Global Health, University of Oxford, Oxford, UK.
Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.

Richard Day (R)

Department of Clinical Pharmacology, St Vincent's Hospital, Sydney, Australia.
St Vincent's Hospital Clinical School, University of New South Wales, Sydney, Australia.
ORCID: 0000-0002-6045-6937

Marlene Fransen (M)

Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.

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Classifications MeSH

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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical risk factors associated with...
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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Clinical risk factors associated with...
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