Safety and Outcomes of Thrombectomy in Ischemic Stroke With vs Without IV Thrombolysis.

Aged Aged, 80 and over Arterial Occlusive Diseases / complications Cerebral Arteries / diagnostic imaging Combined Modality Therapy Female Follow-Up Studies Functional Status Humans Ischemic Stroke / drug therapy Male Middle Aged Outcome Assessment, Health Care Registries / statistics & numerical data Thrombectomy / statistics & numerical data Thrombolytic Therapy / statistics & numerical data

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
24 08 2021
Historique:
received: 01 12 2020
accepted: 20 05 2021
pubmed: 6 6 2021
medline: 4 9 2021
entrez: 5 6 2021
Statut: ppublish

Résumé

To test the hypothesis that IV thrombolysis (IVT) treatment before endovascular thrombectomy (EVT) is associated with better outcomes in patients with anterior circulation large artery occlusion (LAO) stroke, we examined a large real-world database, the Safe Implementation of Treatment in Stroke-International Stroke Thrombectomy Register (SITS-ISTR). We identified centers recording ≥10 consecutive patients in the SITS-ISTR, with at least 70% available modified Rankin Scale (mRS) scores at 3 months during 2014 to 2019. We defined LAO as intracranial internal carotid artery, first and second segment of middle cerebral artery, and first segment of anterior cerebral artery. Main outcomes were functional independence (mRS score 0-2) and death at 3 months and symptomatic intracranial hemorrhage (SICH) per modified SITS-Monitoring Study. We performed propensity score-matched (PSM) and multivariable logistic regression analyses. Of 6,350 patients from 42 centers, 3,944 (62.1%) received IVT. IVT + EVT-treated patients had less frequent atrial fibrillation, ongoing anticoagulation, previous stroke, heart failure, and prestroke disability. PSM analysis showed that IVT + EVT-treated patients had a higher rate of functional independence than patients treated with EVT alone (46.4% vs 40.3%, Pretreatment with IVT was associated with favorable outcomes in EVT-treated LAO stroke in the SITS-ISTR. These findings, while indicative of international routine clinical practice, are limited by observational design, unmeasured confounding, and possible residual confounding by indication. This study provides Class II evidence that IVT before EVT increases the probability of functional independence at 3 months compared to EVT alone.

Identifiants

DOI: 10.1212/WNL.0000000000012327 PMID: 34088873
pubmed: 34088873
pii: WNL.0000000000012327
doi: 10.1212/WNL.0000000000012327
doi:

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e765-e776

Informations de copyright

© 2021 American Academy of Neurology.

Auteurs

Niaz Ahmed (N)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden. niaz.ahmed@ki.se.
ORCID: 0000-0001-7970-0146

Michael Mazya (M)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0002-0377-3506

Ana Paiva Nunes (AP)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0002-5573-1551

Tiago Moreira (T)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Jyrki P Ollikainen (JP)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0001-9869-0414

Irene Escudero-Martínez (I)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0003-1838-0235

Guido Bigliardi (G)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0001-5312-7206

Laura Dorado (L)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Antoni Dávalos (A)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Jose A Egido (JA)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Rossana Tassi (R)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Daniel Strbian (D)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Andrea Zini (A)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0003-1486-4507

Paolo Nichelli (P)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Roman Herzig (R)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Lubomír Jurák (L)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0002-2096-2798

Eva Hurtikova (E)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Georgios Tsivgoulis (G)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Andre Peeters (A)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.
ORCID: 0000-0001-9989-4283

Miroslava Nevšímalová (M)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Miroslav Brozman (M)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Roberto Cavallo (R)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Kennedy R Lees (KR)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Robert Mikulík (R)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Danilo Toni (D)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

Staffan Holmin (S)

From the Department of Neurology (N.A., M.M., T.M.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A., M.M., T.M., S.H.), Karolinska Institutet, Solna, Sweden; Stroke Unit (A.P.N.), Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal; Department of Neurology (J.P.O.), Tampere University Hospital, Tampere, Finland; Department of Neurology (I.E.-M.), University Hospital Virgen del Rocío, Sevilla and Biomedicine Institute of Sevilla, Spain; Department of Neurology (G.B.), Ospedale Civile "S.Agostino-Estense"-Azienda Ospedaliera Universitaria di Modena, Italy; Department of Neurology (L.D., A.D.), Hospital Universitari Germans Trias i Pujol, Badalona; Department of Neurology (J.A.E.), Hospital Clínico San Carlos, Madrid, Spain; Stroke Unit Azienda Ospedaliera Universitaria Senese (R.T.), Siena, Italy; Department of Neurology (D.S.), Helsinki University Central Hospital, Finland; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; Department of Biomedical (P.N.), Metabolical and Neurosciences, Università degli studi di Modena e Reggio Emilia, Italy; Department of Neurology (R.H.), Comprehensive Stroke Centre, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic; Neurocentre (L.J.), Regional Hospital Liberec, Czech Republic; Department of Neurology University Hospital Ostrava (E.H.), Czech Republic; Second Department of Neurology (G.T., A.P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.P.), Cliniques Universitaires St-Luc, Brussels; Department of Neurology (M.N.), Nemocnice Ceske Budejovice, Czech Republic; Constantine the Philosopher University Nitra (M.B.), Faculty of Social Sciences and Health, Slovakia; Department of Neurology (R.C.), Ospedale San Giovanni Bosco, Turin, Italy; School of Medicine (K.R.L.), Dentistry and Nursing, University of Glasgow, UK; International Clinical Research Center and Department of Neurology (R.M.), St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; Department of Human Neurosciences (D.T.), La Sapienza, Rome, Italy; and Department of Neuroradiology (S.H.), Karolinska University Hospital, Solna, Sweden.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Safety and Outcomes of Thrombectomy in...
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questionsmedicales.fr › Thérapeutique › Association thérapeutique › Safety and Outcomes of Thrombectomy in...
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questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Safety and Outcomes of Thrombectomy in...
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questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Safety and Outcomes of Thrombectomy in...
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