Expression and distribution of glutathione transferases in protoscoleces of Echinococcus granulosus sensu lato.
Echinococcus granulosus s.l.
Experimental infection
Gene expression
Glutathione transferases
Immunolocalization
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
28
12
2020
revised:
21
05
2021
accepted:
26
05
2021
pubmed:
6
6
2021
medline:
2
10
2021
entrez:
5
6
2021
Statut:
ppublish
Résumé
Glutathione transferases (GSTs) belong to a diverse superfamily of multifunctional proteins involved in metabolic detoxification. In helminth parasite, GSTs are particularly relevant since they are also involved in host immunomodulation. Echinococcus granulosus sensu lato (s.l.) is a cestode parasite known to express at least three phylogenetically distant cytosolic GSTs: EgGST1 and EgGST2 previously grouped within Mu and Sigma classes, respectively; and EgGST3 related to both Omega and Sigma classes. To better characterize E. granulosus s.l. GSTs, herein their expression and distribution were assessed in the pre-adult protoscolex (PSC) parasite stage. Potential transcriptional regulatory mechanisms of the corresponding EgGST genes were also explored. Firstly, the transcription of the three EgGSTs was significantly induced during the early stages of the murine model of infection, suggesting a potential role during parasite establishment. EgGST1 was detected in the parenchyma of PSCs and its expression increased after H
Identifiants
pubmed: 34089697
pii: S0001-706X(21)00170-4
doi: 10.1016/j.actatropica.2021.105991
pii:
doi:
Substances chimiques
Anthelmintics
0
Hydrogen Peroxide
BBX060AN9V
Glutathione Transferase
EC 2.5.1.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105991Informations de copyright
Copyright © 2021. Published by Elsevier B.V.