WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis.
Fetal liver endothelium
Hematopoiesis
Organ-specific
WNT5A
Journal
Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581
Informations de publication
Date de publication:
05 06 2021
05 06 2021
Historique:
received:
04
07
2020
accepted:
10
05
2021
entrez:
6
6
2021
pubmed:
7
6
2021
medline:
13
7
2021
Statut:
epublish
Résumé
The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fetal development. Here, we demonstrate that human fetal liver endothelium uniquely supports the maturation and expansion of multilineage HSPCs. Specifically, co-culture of fetal liver-derived immature CD43
Identifiants
pubmed: 34090485
doi: 10.1186/s13287-021-02380-z
pii: 10.1186/s13287-021-02380-z
pmc: PMC8180064
doi:
Substances chimiques
WNT5A protein, human
0
Wnt-5a Protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
321Subventions
Organisme : NHLBI NIH HHS
ID : K08HL140143
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL141570
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32DK102336
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC2 DK114777
Pays : United States
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