Thromboprophylaxis strategies to improve the prognosis of COVID-19.
Anticoagulant
COVID-19
Coagulation
Deep venous thrombosis
Pulmonary embolism
Thromboprophylaxis
Journal
Vascular pharmacology
ISSN: 1879-3649
Titre abrégé: Vascul Pharmacol
Pays: United States
ID NLM: 101130615
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
23
02
2021
revised:
06
05
2021
accepted:
02
06
2021
pubmed:
7
6
2021
medline:
29
7
2021
entrez:
6
6
2021
Statut:
ppublish
Résumé
The outbreak of 2019 novel coronavirus disease (Covid-19) has deeply challenged the world population, but also our medical knowledge. Special attention has been paid early to an activation of coagulation, then to an elevated rate of venous thromboembolism (VTE) in patients hospitalized with severe COVID-19. These data suggested that anticoagulant drugs should be evaluated in the treatment of patients with COVID-19. The publication of unexpected high rates of VTE in patients hospitalized with COVID-19, despite receiving thromboprophylaxis, open the way to dedicated trials, evaluating modified regimens of thromboprophylaxis. Moreover, the further improvement in our comprehension of the disease, particularly the pulmonary endothelial dysfunction increased the hope that anticoagulant drugs may also protect patients from pulmonary thrombosis. In this comprehensive review, we cover the different situations where thromboprophylaxis standard may be modified (medically-ill inpatients, ICU inpatients, outpatients), and describe some of the current randomized controls trials evaluating new regimens of thromboprophylaxis in patients with COVID-19, including the preliminary available results. We also discuss the potential of anticoagulant drugs to target the thromboinflammation described in patients with severe COVID-19.
Identifiants
pubmed: 34091065
pii: S1537-1891(21)00055-0
doi: 10.1016/j.vph.2021.106883
pmc: PMC8177305
pii:
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106883Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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