Water-soluble alkaloids isolated from Portulaca oleracea L.
Alkaloids
/ chemistry
Animals
Anti-Inflammatory Agents
/ chemistry
Crystallography, X-Ray
Edema
/ chemically induced
Interleukin-6
/ metabolism
Lipopolysaccharides
/ pharmacology
Macrophages
/ cytology
Male
Mice
Molecular Conformation
Nitric Oxide
/ metabolism
Plant Extracts
/ chemistry
Portulaca
/ chemistry
RAW 264.7 Cells
Solubility
Water
/ chemistry
Anti-inflammatory activity
Portulaca oleracea L.
Water-soluble alkaloids
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
30
03
2021
revised:
16
05
2021
accepted:
24
05
2021
pubmed:
7
6
2021
medline:
26
10
2021
entrez:
6
6
2021
Statut:
ppublish
Résumé
Fifteen new water-soluble alkaloids were obtained from the fresh herbs of Portulaca oleracea L. The structures of 15 alkaloids 1-15 were established according to spectroscopic data, and the stereoconfigurations were determined based on experimental and calculated electronic circular dichroism (ECD) data and single crystal X-ray diffraction. Alkaloids 1-15 were found to display good anti-inflammatory activity at 10 μM and could significantly reduce the interleukin-6 (IL-6) and nitric oxide (NO) levels induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages.
Identifiants
pubmed: 34091292
pii: S0045-2068(21)00400-4
doi: 10.1016/j.bioorg.2021.105023
pii:
doi:
Substances chimiques
Alkaloids
0
Anti-Inflammatory Agents
0
Interleukin-6
0
Lipopolysaccharides
0
Plant Extracts
0
Water
059QF0KO0R
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105023Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.