Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.
CYP2C19
CYP2D6
OCT1
SLC22A1
amitriptyline
drug transport
nortriptyline
organic cation transporter 1
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
03
2021
accepted:
04
05
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
8
6
2021
Statut:
epublish
Résumé
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cytochrome P450 (CYP) 2D6 and 2C19, genetic polymorphism of the hepatic influx transporter organic cation transporter 1 (OCT1) could be contributing to interindividual variation in pharmacokinetics. Here, the impact of OCT1 genetic variation on the pharmacokinetics of amitriptyline and its active metabolite nortriptyline was studied
Identifiants
pubmed: 34093211
doi: 10.3389/fphar.2021.688950
pii: 688950
pmc: PMC8175851
doi:
Types de publication
Journal Article
Langues
eng
Pagination
688950Informations de copyright
Copyright © 2021 Matthaei, Brockmöller, Steimer, Pischa, Leucht, Kullmann, Jensen, Ouethy, Tzvetkov and Rafehi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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