Case Report: Unmasking Hypercalcemia in Patients With Neuroendocrine Neoplasms. Experience From Six Italian Referral Centers.
1,25-dihydroxyvitamin D
bronchial carcinoid
pancreatic NEN
paraneoplastic hypercalcemia
parathyroid hormone-related protein
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
02
2021
accepted:
27
04
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Hypercalcemia is a common paraneoplastic syndrome which can occur in up to 10% of patients with advanced neoplasms. Paraneoplastic parathyroid hormone-related protein (PTHrP) represents the most frequent cause of this syndrome. In neuroendocrine neoplasms (NENs) paraneoplastic hypercalcemia is rare. The present series includes all patients with NENs and paraneoplastic hypercalcemia from four Italian centres: In our series, paraneoplastic PTHrP-related hypercalcemia occurred in pancreatic NEN and in one bronchial carcinoid representing the third case in the literature. Our case associated with 1,25-dihydroxyvitamin D secretion represents the fourth case in the literature. PTHrP secretion should be considered in NENs' patients with hypercalcemia. Acute treatment should be focused on lowering calcium levels, and long-term control can be achieved by tumor cytoreduction inhibiting PTHrP release.
Sections du résumé
Background
Hypercalcemia is a common paraneoplastic syndrome which can occur in up to 10% of patients with advanced neoplasms. Paraneoplastic parathyroid hormone-related protein (PTHrP) represents the most frequent cause of this syndrome. In neuroendocrine neoplasms (NENs) paraneoplastic hypercalcemia is rare.
Case Series
The present series includes all patients with NENs and paraneoplastic hypercalcemia from four Italian centres:
Conclusion
In our series, paraneoplastic PTHrP-related hypercalcemia occurred in pancreatic NEN and in one bronchial carcinoid representing the third case in the literature. Our case associated with 1,25-dihydroxyvitamin D secretion represents the fourth case in the literature. PTHrP secretion should be considered in NENs' patients with hypercalcemia. Acute treatment should be focused on lowering calcium levels, and long-term control can be achieved by tumor cytoreduction inhibiting PTHrP release.
Identifiants
pubmed: 34093441
doi: 10.3389/fendo.2021.665698
pmc: PMC8170398
doi:
Substances chimiques
Vitamin D
1406-16-2
1,25-dihydroxyvitamin D
66772-14-3
Types de publication
Case Reports
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
665698Informations de copyright
Copyright © 2021 Giannetta, Sesti, Modica, Grossrubatscher, Guarnotta, Ragni, Zanata, Colao and Faggiano.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
N Engl J Med. 2005 Jan 27;352(4):373-9
pubmed: 15673803
J Clin Endocrinol Metab. 2012 Sep;97(9):2990-3011
pubmed: 22723327
Medicine (Baltimore). 2016 Jan;95(3):e2419
pubmed: 26817871
Endocrine. 2019 May;64(2):384-392
pubmed: 30280284
Clin Endocrinol (Oxf). 1985 Feb;22(2):135-46
pubmed: 4039233
Eur J Endocrinol. 2020 Dec;183(6):R197-R215
pubmed: 33112280
J Gastrointest Oncol. 2014 Aug;5(4):E84-7
pubmed: 25083313
BMJ Case Rep. 2017 Nov 23;2017:
pubmed: 29170170
Rev Endocr Metab Disord. 2017 Dec;18(4):433-442
pubmed: 28868578
Horm Metab Res. 2010 Mar;42(3):153-64
pubmed: 19960404
Endocr Pathol. 2017 Dec;28(4):351-361
pubmed: 29063495
J Oncol Pract. 2016 May;12(5):426-32
pubmed: 27170690
Int J Mol Sci. 2019 Jun 22;20(12):
pubmed: 31234481
Thyroid. 2015 Jun;25(6):567-610
pubmed: 25810047
Ann Intern Med. 1987 Mar;106(3):476-7
pubmed: 3813248
J Surg Case Rep. 2019 Dec 09;2019(12):rjz346
pubmed: 31832136
Neoplasia. 2017 Dec;19(12):991-1002
pubmed: 29091800
CA Cancer J Clin. 2018 Sep;68(5):377-386
pubmed: 30240520
J Clin Endocrinol Metab. 2003 Apr;88(4):1603-9
pubmed: 12679445
J Clin Endocrinol Metab. 2014 Sep;99(9):3060-9
pubmed: 24905065
Endocr Relat Cancer. 2017 Jun;24(6):R173-R190
pubmed: 28341725
Ann Intern Med. 1990 Apr 1;112(7):499-504
pubmed: 2138442