Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor.
AhR
aryl hydrocarbon receptor
immunity
intestine
microbiota
tryptophan
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
12
2020
accepted:
07
05
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
24
9
2021
Statut:
epublish
Résumé
Accumulating evidence indicates that nutrition can modulate the immune system through metabolites, either produced by host digestion or by microbiota metabolism. In this review, we focus on dietary metabolites that are agonists of the Aryl hydrocarbon Receptor (AhR). AhR is a ligand-activated transcription factor, initially characterized for its interaction with xenobiotic pollutants. Numerous studies have shown that AhR also recognizes indoles and tryptophan catabolites originating from dietary compounds and commensal bacteria. Here, we review recent work employing diet manipulation to address the impact of nutritional AhR agonists on immune responses, both locally in the intestine and at distant sites. In particular, we examine the physiological role of these metabolites in immune cell development and functions (including T lymphocytes, innate-like lymphoid cells, and mononuclear phagocytes) and their effect in inflammatory disorders.
Identifiants
pubmed: 34093534
doi: 10.3389/fimmu.2021.645168
pmc: PMC8173196
doi:
Substances chimiques
AHR protein, human
0
Basic Helix-Loop-Helix Transcription Factors
0
Ligands
0
Receptors, Aryl Hydrocarbon
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
645168Informations de copyright
Copyright © 2021 De Juan and Segura.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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