The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value.
bioinformatics
hephaestin
immunohistochemistry
iron
lung cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
12
2020
accepted:
26
04
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression, possibly by stimulating cell proliferation due to an increase in iron availability, has shown to correlate with poor survival in breast cancer. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tension present, however, HEPH distribution in lung cancer and its influence on prognosis have not been investigated yet. In this study we explored the prognostic value of HEPH and its expression pattern in the most prevalent histotypes of lung cancers, namely lung adenocarcinoma and lung squamous cell carcinoma.
Identifiants
pubmed: 34094919
doi: 10.3389/fonc.2021.638856
pmc: PMC8170403
doi:
Types de publication
Journal Article
Langues
eng
Pagination
638856Informations de copyright
Copyright © 2021 Zacchi, Belmonte, Mangogna, Morello, Scola, Martorana and Borelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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