Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma.
adjuvanticity
antigenicity
glioblastoma
immunosuppression
immunotherapy
radiotherapy
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
02
2021
accepted:
13
04
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal prognoses, monotherapy with IT in GBM has shown minimal response in first recurrence. Recent discoveries in lymphatics and evaluation of blood brain barrier offer insight to improve the use of ITs and determine the best combinations of therapies, including radiation. We highlight important features of the tumor immune microenvironment in GBM and potential for combining radiation and immunotherapy to improve prognosis in this devastating disease.
Identifiants
pubmed: 34094969
doi: 10.3389/fonc.2021.671044
pmc: PMC8173136
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
671044Subventions
Organisme : NCI NIH HHS
ID : R38 CA231577
Pays : United States
Informations de copyright
Copyright © 2021 De Martino, Padilla, Daviaud, Wu, Gartrell and Vanpouille-Box.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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