The Sulfation Code of Tauopathies: Heparan Sulfate Proteoglycans in the Prion Like Spread of Tau Pathology.
2-O and 6-O sulfated heparins
3-O sulfation
Alzheimer’s disease
glycobiology
heparan sulfate
neurodegenerative diseases
prions and prion disease
tauopathies
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
02
2021
accepted:
12
04
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined by the appearance of proteinaceous lesions within the brain composed of abnormally folded species of Microtubule Associated Protein Tau (tau). Alzheimer's Disease (AD), the most common tauopathy, is the leading cause of cognitive decline among the elderly and is responsible for more than half of all cases of senile dementia worldwide. The characteristic pathology of many tauopathies-AD included-presents as Neurofibrillary Tangles (NFTs), insoluble inclusions found within the neurons of the central nervous system composed primarily of tau protein arranged into Paired Helical Fibrils (PHFs). The spatial extent of this pathology evolves in a remarkably consistent pattern over the course of disease progression. Among the leading hypotheses which seek to explain the stereotypical progression of tauopathies is the
Identifiants
pubmed: 34095227
doi: 10.3389/fmolb.2021.671458
pmc: PMC8173255
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
671458Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103390
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG062344
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG069039
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG074289
Pays : United States
Informations de copyright
Copyright © 2021 Mah, Zhao, Liu, Zhang, Liu, Wang, Linhardt and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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